ISSN:
1436-5073
Keywords:
spectrophotometric
;
titrimetric
;
sulfa drugs
;
vitamin-C
;
N-chlorosuccinimide
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract New spectrophotometric and titrimetric methods for the determination of sulphonamides withN-chlorosuccinimide (NCS) were developed. The spectrophotometric measurements can be made at 324–395 nm at pH 7.4 at room temperature, the stoichiometry being 1: 2, (p-H2N-C6H4-SO2NHR): (NCS) forming a dibromination product in presence of acidified potassium bromide. Potentiometrically or visually using methyl red as indicator, sulphonamides are titrated in pharmaceutical preparations by NCS always in presence of acidified potassium bromide. Ascorbic acid is determined alone and also in combinations, by first titrating it using potassium iodide and starch or 2,6-dichlorophenolindophenol as indicator. Acylation or diazotization of the aromatic amino groups that prevents substitution at the two ortho positions, is used as additional prereaction to analyze various binary and ternary mixtures of certain sulphonamides. These methods are accurate, simple, rapid, reproducible, useful at higher concentrations, do not involve any preseparation, and can tolerate several compounds that cause interference in other methods.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01242793
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