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  • 1
    Electronic Resource
    Electronic Resource
    DI-DESOXYRIBONUCLEOTIDES1 (1952)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 74 (1952), S. 283-283 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01121a531
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    ASSESMENT OF BACTERIAL PATHOGENESIS BY ANALYSIS OF GENE EXPRESSION IN THE HOST (2000)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Genetics 34 (2000), S. 139-164 
    Details
    ISSN: 0066-4197
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract A number of techniques have been developed to assess the expression of microbial virulence genes within the host (in vivo). These studies have shown that bacteria employ a wide variety of mechanisms to coordinately regulate the expression of these genes during infection. Two tenets have emerged from these studies: bacterial adaptation responses are critical to growth within the host, and interactions between microorganisms and the microenvironments of their hosts cannot be revealed from in vitro studies alone. Results that support these tenets include (i) the prevalent class of in vivo expressed genes are involved in adaptation to environmental stresses, (ii) pathogens recovered from host tissues (versus laboratory growth) are often more resistant to host killing mechanisms, and (iii) virulence gene expression can differ in the animal compared to laboratory media. Thus, pathogenicity comprises the unique ability to adapt to the varied host milieus encountered as the infection proceeds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.genet.34.1.139
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  • 3
    Electronic Resource
    Electronic Resource
    New method for isolation and sequence determination of 5'-terminal regions of bacteriophage φX174 in vitro mRNAs (1975)
    s.l. : American Chemical Society
    Biochemistry 14 (1975), S. 1951-1955 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00680a023
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The pure and the applied (1987)
    [s.l.] : Nature Publishing Group
    Nature 325 (1987), S. 669-669 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN UNDER a decade, a whole new industry, capitalized with many billions of dollars, has come into being. Such is the rate of change in the late twentieth century. The product of 30 years of government support of basic biomedical research, biotechnology emerged from its incubator in the mid-1970s ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/325669a0
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  • 5
    Electronic Resource
    Electronic Resource
    Denaturation of RNA with dimethyl sulfoxide (1968)
    New York : Wiley-Blackwell
    Biopolymers 6 (1968), S. 793-807 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The denaturation of single-stranded and double-stranded RNA's in solutions with varying proportions of dimethyl sulfoxide has been followed by changes in absorbancy, optical rotation, and - with a double-stranded form of bacteriophage of MS2 RNA -  infectivity for bacterial spheroplasts. By these criteria the RNA's studied, including the synthetic polynucleotide rG:rC, are completely denatured at room temperature in high concentrations of this solvent. In lower concentrations, the Tm of the RNA preparation is decreased only slightly as the dimethyl sulfoxide concentration is raised until a critical concentration is reached. The Tm falls sharply with small further increases in dimethyl sulfoxide concentration. Sedimentation studies can be conducted directly in these media. The determination of sedimentation velocity in 99% dimethyl sulfoxide containing 0.001M EDTA provides a reliable estimate of RNA molecular weights.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.1968.360060604
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  • 6
    Electronic Resource
    Electronic Resource
    DNA virus maturation (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 74 (1969), S. 21-32 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Maturation of bacterial viruses requires the formation of mature viral nucleic acid in the form found in progeny virus particles, the “packaging” of this viral nucleic acid within a capsule, and the assembly of “packaged” nucleic acid with the accessory structures necessary for infectivity. Recognition that the replicating viral nucleic acid is frequently in a form distinct from that found in mature particles has, in some instances, led to the postulation and formal description of presently unknown processes that must participate in the synthesis of the mature form. In at least some instances, packaging of the mature nucleic acid is clearly integrated with its synthesis.Examples involving the DNA bacteriophages T4, λ, and φ X174 and the RNA bacteriophages are presented to illustrate these points.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040740404
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    The discovery of a singlestranded, circular DNA genome (1991)
    New York, NY : Wiley-Blackwell
    BioEssays 13 (1991), S. 89-91 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950130209
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    Paper (German National Licenses)
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