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  • 1
    Electronic Resource
    Electronic Resource
    Some central pharmacological effects of (+)- and (−)-oxaprotiline (1990)
    Springer
    Journal of neural transmission 80 (1990), S. 129-143 
    Details
    ISSN: 1435-1463
    Keywords: (+)- and (−)-oxaprotiline ; pharmacology ; central effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The central action of oxaprotiline (OXA) enantiomers, administered in a single dose, was studied in rats and mice. (+)-OXA and (−)-OXA attenuated reserpine- and apomorphine-induced hypothermia [(+)-OXA in a more potent manner] in mice and reduced the immobility time in the behavioural despair test in rats. Both OXA enantiomers inhibited locomotor activity in mice and rats, and enhanced and prolonged amphetamine- and apomorphine-induced stereotypy in rats. (−)-OXA potentiated the amphetamine hyperactivity in rats, but not in mice. Nomifensine hyperactivity in rats was unaffected by either enantiomer, and locomotor hypoactivity induced by low doses of apomorphine was also unchanged, as was L-DOPA-induced locomotor hyperactivity in mice. Apomorphine-induced climbing in mice was attenuated by (+)-OXA. Clonidine locomotor hypoactivity and hypothermia were unchanged, and clonidine-induced aggressiveness was attenuated by (+)-OXA. Neither OXA enantiomer affected the action of oxotremorine. In some tests the effect of OXA was stronger at 3 h than at 1 h after administration. The above results indicate that both OXA enantiomers—in particular (−)-OXA—increase some dopaminergic behavioural effects in rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01257078
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of chronic treatment with antidepressants on aggressiveness induced by clonidine in mice (1982)
    Springer
    Journal of neural transmission 55 (1982), S. 19-25 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It has previously been found that a number of typical and atypical antidepressants, given chronically, intensify clonidine-induced aggressiveness in mice. Further experiments now show that chronic, but not acute, administration of nisoxetine, a selective inhibitor of noradrenaline uptake, potentiates clonidine-induced aggressiveness. Citalopram and fluvoxamine, two selective inhibitors of serotonin uptake, have no such action. Of the two isomers of flupenthixol, only thetrans-form, potentiates clonidine-induced aggressiveness in chronic experiments. Thecis-form induces an inhibiting effect. Clonidine-induced aggressiveness is also intensified by chronic, but not by acute, administration of pizotifen, an antagonist of serotonin and noradrenaline. The results seem to support the previous hypothesis that potentiation of clonidine-induced aggressiveness is mediated by anα 1-adrenergic mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01243338
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  • 3
    Electronic Resource
    Electronic Resource
    Roxindole, a potential antidepressant I. Effect on the dopamine system (1996)
    Springer
    Journal of neural transmission 103 (1996), S. 627-641 
    Details
    ISSN: 1435-1463
    Keywords: Roxindole ; dopamine system ; antidepressant activity ; rats ; mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Roxindole (EMD 49980, 5-hydroxy-3-[4-(4-phenyl-1,2,3,6-tetrahydropyridyl(1))-butyl(1)]-indole mesylate), a selective dopamine autoreceptor agonist and a potential antipsychotic drug, shows a clinical antidepressant efficacy. The present paper examined the neuropharmacological profile of roxindole in rats (male Wistar) and mice (male Albino Swiss) in respect of its influence on dopamine system. Used in low doses, roxindole decreased the locomotor activity, but in higher ones it did not induce a locomotor hyperactivity or stereotypy. It antagonized the amphetamine-induced hyperlocomotion, the amphetamine- or apomorphine-induced stereotypy, apomorphine climbing behaviour and reserpine-induced akinesia. The quinpirole-induced hyperlocomotion was inhibited by roxindole. When given alone, the drug in question, did not induce the catalepsy, but antagonized the catalepsy induced by haloperidol, spiperone and fluphenazine. The immobility time in the forced swimming test was reduced. Like typical antidepressants, roxindole given repeatedly (twice daily, 14 days) increased the hyperlocomotion induced by D-amphetamine. The results described above indicate that roxindole may have an antidepressant and antiparkinsonian activity and should be devoid of extrapyramidal side-effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01273159
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  • 4
    Electronic Resource
    Electronic Resource
    The anticataleptic effect of 7-OH-DPAT: are dopamine D3 receptors involved? (1999)
    Springer
    Journal of neural transmission 106 (1999), S. 1063-1073 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: 7-OH-DPAT, nafadotride, catalepsy, D3 receptors, rat.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. The paper examined the effect of 7-OH-DPAT (7-hydroxy-N,N-di-n-propyl-2-aminotetralin), a dopamine D3 receptors-prefering agonist, on the catalepsy evoked by reserpine, haloperidol and fluphenazine in rats (male Wistar), as well as the influence of nafadotride, a dopamine D3 receptors-prefering antagonist, on that effect. The obtained results show that 7-OH-DPAT, as well as L-DOPA, a drug of choice in the therapy of Parkinson's disease, used for comparison, antagonize the catalepsy induced by reserpine, haloperidol and fluphenazine. Nafadotride, used in a dose (0.2 mg/kg) which inhibits the 7-OH-DPAT-evoked locomotor hyperactivity but does not affect the hypermotility induced by amphetamine and quinpirole, antagonizes the anticataleptic effect of 7-OH-DPAT or L-DOPA. It is therefore assumed that dopamine D3 receptors are involved in the anticataleptic effect of both 7-OH-DPAT and L-DOPA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020050223
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  • 5
    Electronic Resource
    Electronic Resource
    Repeated treatment with antidepressant drugs increases the behavioural response to apomorphine (1984)
    Springer
    Journal of neural transmission 60 (1984), S. 273-282 
    Details
    ISSN: 1435-1463
    Keywords: Antidepressants ; repeated treatment ; apomorphine ; open field test ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of repeated treatment (twice a day for 14 days) with antidepressant drugs (AD): imipramine, amitriptyline, zimelidine, citalopram and mianserin on the behavioural response to apomorphine in rats (open field test) was investigated. AD studied, given alone in a single dose or repeatedly, do not change the rats behaviour. A repeated but not single-dose treatment with AD facilitates the behaviour stimulation induced by apomorphine. This facilitation is observed 2 hours after the last dose of imipramine, zimelidine, citalopram and mianserin but 72 hours after the last dose of amitriptyline. The results presented suggest that the AD given repeatedly are able to increase the responsiveness of the brain DA system, probably the mesolimbic one.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01249099
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  • 6
    Electronic Resource
    Electronic Resource
    Pharmacological properties of EXP 561, a potential antidepressant drug (1987)
    Springer
    Journal of neural transmission 70 (1987), S. 81-97 
    Details
    ISSN: 1435-1463
    Keywords: EXP 561 ; acute antidepressive effects ; adaptive changes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The compound EXP 561 (1-amino-4-phenylbicyclo-[2, 2, 2]-octane), an inhibitor of the noradrenaline (NA), 5-hydroxytryptamine (5-HT) and dopamine (DA) uptake, a potential antidepressant agent, was studied in tests for evaluation of antidepressant drugs (AD). In most experiments (the apomorphine and reserpine hypothermia, the behavioural despair test, the blood pressure increases induced by NA and 5-HT) EXP 561 revealed similar activities as tricyclic AD. EXP 561 evoked stimulation of the hind limb flexor reflex in spinal rats, blocked by prazosin, metergoline and clomipramine. EXP 561 administered repeatedly in mice (twice daily for 14 days) did not evoke the adaptive changes induced by AD inhibiting the amine uptake, i.e. it did not enhance the amphetamine locomotor hyperactivity, did not potentiate the clonidine aggressiveness (at a lower dose, while at a higher one it acted less potently than when given acutely) or did not change the reserpine effect on the locomotor activity. EXP 561 showed a poor affinity toα 1-adrenoceptor (IC50 was 135,000 nM). The results indicate that the inability to induce adaptive changes is a feature which differentiates EXP 561 from tricyclic AD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01252511
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  • 7
    Electronic Resource
    Electronic Resource
    The influence of repeated treatment with imipramine, (+)- and (−)-oxaprotiline on behavioural effects of dopamine D-1 and D-2 agonists (1989)
    Springer
    Journal of neural transmission 76 (1989), S. 29-38 
    Details
    ISSN: 1435-1463
    Keywords: Antidepressant drugs ; SKF 38393 ; quinpirole ; nucleus accumbens ; grooming ; locomotor activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The paper examined the action of imipramine, (+)- and (−)-oxaprotiline, administered repeatedly to rats, on the behavioural effects of the dopamine D-1 and D-2 agonists, SKF 38393 and quinpirole, respectively. The three antidepressants studied, given in the single dose or repeatedly, attenuate the enhanced grooming evoked by SKF 38393. The locomotor hyperactivity, evoked by quinpirole administered s.c., is increased by repeated but not single-dose treatment with imipramine and (+)-oxaprotiline [but not with (−)-oxaprotiline]. Quinpirole at a low dose produces the locomotor hypoactivity which is attenuated by repeated, but not single-dose, treatment with the antidepressants studied here. Repeated imipramine and (+)-oxaprotiline [but not (−)-oxaprotiline] increase the locomotor activity effect of quinpirole injected into the nucleus accumbens. The results indicate that the enhanced responsiveness of the dopamine system, observed previously after repeated treatment with antidepressants, may be mediated by the dopamine D-2 receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244989
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  • 8
    Electronic Resource
    Electronic Resource
    Antidepressants given repeatedly increase the behavioural effect of dopamine D-2 agonist (1989)
    Springer
    Journal of neural transmission 78 (1989), S. 1-8 
    Details
    ISSN: 1435-1463
    Keywords: Antidepressants ; repeated treatment ; dopamine D-2 agonist ; behaviour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of single or repeated doses of antidepressant drugs (imipramine, amitriptyline, citalopram, mianserin) on rat locomotor hyperactivity induced by quinpirole, a dopamine D-2 receptor agonist, was investigated. Single doses of antidepressants do not change the effect of quinpirole, but enhance it when they are administered repeatedly. This enhancement is inhibited by (±)-sulpiride, a dopamine D-2 receptor antagonist. The results obtained indicate that the enhancement of dopaminergically-stimulated hyperactivity induced by repeated doses of antidepressants is mediated by dopamine D-2 receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01247108
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  • 9
    Electronic Resource
    Electronic Resource
    Some central effects of CGP 37849 and CGP 39551, the competitive NMDA receptor antagonists: potential antiparkinsonian activity (1993)
    Springer
    Journal of neural transmission 6 (1993), S. 53-62 
    Details
    ISSN: 1435-1463
    Keywords: CGP 37849 and CGP 39551 ; monoamine-depleted rats ; locomotor activity ; neuroleptic catalepsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two new competitive NMDA receptor antagonists with oral activity CGP 37849 (D,L-E-amino-methyl-phosphono-3-pentenoic acid) and its ethyl ester CGP 39551 were studied in rats. CGP 37849 did not change the locomotor activity or increased it. The hyperactivity induced by CGP 37849 was antagonized by haloperidol but not idazoxan or prazosin. CGP 39551 decreased the locomotor activity. The studied compounds did not increase the locomotion in monoamine-depleted (pretreated with reserpine and α-methyl-p-tyrosine) rats. Clonidine induced antiakinetic effect in monoamine-depleted rats. This effect was more pronounced after joint administration of clonidine and CGP 37849 or CGP 39551. The locomotor hyperactivity induced by joint dministration of CGP 37849 and clonidine was inhibited by haloperidol but not prazosin or idazoxan. CGP 37849 but not CGP 39551 also enhanced antiakinetic effect of L-DOPA (given together with benserazide) in monoamine-depleted rats. CGP 37849 antagonized the spiperone- and fluphenazine-induced catalepsy; CGP 39551 had considerably weaker antagonistic effect. The reserpine-induced catalepsy was attenuated by CGP 37849. MK-801, a non-competitive NMDA antagonist inhibited spiperone- but not reserpine-induced catalepsy. The obtained results indicate that CGP 37849 administered alone or in combination with L-DOPA or clonidine may be a potential antiparkinsonian drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02252623
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  • 10
    Electronic Resource
    Electronic Resource
    Antidepressant drugs increase the locomotor hyperactivity induced by MK-801 in rats (1991)
    Springer
    Journal of neural transmission 85 (1991), S. 169-179 
    Details
    ISSN: 1435-1463
    Keywords: MK-801 ; locomotor hyperactivity ; lantidepressants ; repeated treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary MK-801, a non-competitive NMDA receptor antagonist, induced the locomotor hyperactivity in rats. Imipramine (IMI), amitriptyline (AMI), citalopram (CIT) given acutely increased the MK-801-induced locomotor hyperactivity. Mianserin (MIA) showed a similar but weaker effect. Haloperidol completely blocked the hyperactivity induced by the antidepressant drug (AD) + MK-801. Prazosin had an only weak antagonistic effect. Repeated treatment with AD increased the MK-801 locomotor hyperactivity to a greater extent than acute treatment. This effect was completely blocked by haloperidol and only partly by prazosin. The obtained results indicate that the dopamine system may be involved, at least in part, in the potentiating effect of the combined treatment with AD + MK-801.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244943
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