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Diagnosis of congenital toxoplasmosis at birth: what is the value of testing for IgM and IgA? (1999)

Wallon, M. ; Dunn, D. ; Slimani, D. ; [et al.]

Springer

European journal of pediatrics 158 (1999), S. 645-649

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ISSN: 1432-1076

Keywords: Key words Congenital toxoplasmosis ; IgM antibodies ; IgA antibodies ; Diagnosis ; Birth

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Recommandations vary on the best combination of tests to use for the diagnosis of subclinical congenital toxoplasmosis at birth. The diagnostic accuracy of IgM and IgA tests was assessed in the context of routine clinical practice on 233 newborns with congenital toxoplasmosis and 661 healthy controls. IgM/IgA sensibility and specificity were compared in cord and postnatal samples. Both tests were considerably more specific in neonatal blood (IgM: 98%; IgA: 100%) than in cordblood (IgM: 85%; IgA: 88%). Sensitivity for IgM and IgA was not significantly different in neonatal blood (61% and 60%, respectively) and cord blood (67% and 54%, respectively). Combining IgM and IgA increased the overall sensitivity to 73% without any significant loss in specificity (98%). The influence of the date of maternal infection on the sensitivity and negative predictive value was also clearly demonstrated. Conclusion Because of their relatively low cost compared to more sophisticated methods, IgM and IgA tests should remain the main method for the routine diagnosis of congenital toxoplasmosis although follow up is essential to identify the Ca. 25% of infected children who are missed at birth on the basis of these tests.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s004310051168

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A finite difference algorithm for plotting electric force surface in three-dimensional field computation (1995)

Slimani, D. ; Djellal, K. ; Chemali, H. ; [et al.]

Chichester : Wiley-Blackwell

Communications in Numerical Methods in Engineering 11 (1995), S. 1033-1038

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ISSN: 1069-8299

Keywords: electric field ; vector potential ; electrostatic ; electric force surface ; curve integral ; Engineering ; Engineering General

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Mathematics , Technology

Notes: A finite difference algorithm for plotting the electric force surface is presented in three-dimensional electrostatic field computation. Based on the flux concept, the nodal electric flux is calculated numerically through the curve integral of the electric displacement vector which was obtained by a numerical differentiation of the nodal electric potential. This latter is calculated by a finite difference method. The electric force surface may also be plotted.

Additional Material: 4 Ill.