ISSN:
1573-8388
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary 1. Derivatives of the polypeptide antibiotic A-128-OP at positions 1, 2, and 3 of the indole rings of the β-methyltryptophan and dehydrotryptophan residues have been obtained for the first time, and their physicochemical properties have been studied. 2. The introduction into the antibiotic molecule of a 2-hydroxy-5-nitrobenzyl or a 2-nitrophenyl-sulfenyl substituent lower its antibacterial activity 15- to 20-fold. The replacement of the hydrogen atoms in positions 1 of the indole rings of the β-methyltryptophan and dehydrotryptophan residues leads to a 4-to 5-fold decrease in the activity of antibiotic A-128-OP.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00567860
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