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  • 1
    Electronic Resource
    Electronic Resource
    Isomerization of Dienæstrol (1948)
    [s.l.] : Nature Publishing Group
    Nature 161 (1948), S. 892-893 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] DURING experiments on the metabolism of dienœstrol in man and in animals it was noticed that hydrolysis of diencestrol-containing urines, 1 N with respect to hydrochloric acid, always entailed a loss of about 90 per cent of the original œstrogenic activity. Further, chemical determination of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/161892b0
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  • 2
    Electronic Resource
    Electronic Resource
    Metabolism of Synthetic Œstrogens in Man (1947)
    [s.l.] : Nature Publishing Group
    Nature 160 (1947), S. 787-787 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IT has long been the practice in carrying out phenol metabolism experiments in animals to measure the increase in ethereal sulphate excretion above the normal average to give an indication of the extent to which the phenol in question is being excreted by sulphate formation. Similarly, a rise ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/160787a0
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  • 3
    Electronic Resource
    Electronic Resource
    Determination of Dienoestrol in Biological Samples (1946)
    [s.l.] : Nature Publishing Group
    Nature 157 (1946), S. 697-697 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE widespread clinical and veterinary use of the synthetic œstrogens has made it desirable to be able to assay these substances in biological samples, but until now no practical chemical method has been reported, although Dingemanse1 and Malpress2 have published ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/157697a0
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  • 4
    Electronic Resource
    Electronic Resource
    Über die Herstellung und physiologischen Eigenschaften einiger Acetylenverbindungen und verwandter Stoffe. 2. Mitteilung. Über die Umlagerung von 3,4-Di-p-anisyl-3-ol-hexin-(1) (1953)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 36 (1953), S. 1949-1955 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Attempts to remove water from 3,4-di-p-anisyl-1-hexyn-3-ol in acid medium resulted in rearrangement according to Meyer-Schuster principally and to Rupe to a minor extent. None of the derivatives of these rearrangement products reached the oestrogenicity of stilboestrol. The dehydration of 3,4-di-p-anisyl-3-hexen-2-ol does not lead to the expected diene but to the corresponding methylether of the known 1-ethyl-2-p-hydroxyphenyl-3-methyl-5-hydroxyindene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19530360734
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  • 5
    Electronic Resource
    Electronic Resource
    Influence des substituants sur la vitesse de racémisation des cétones à carbone dissymétrique en alpha (1960)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 43 (1960), S. 1915-1927 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The rates of racemisation, under constant conditions of pH and temperature, of two series of ketones with an asymmetric C-atom in α have been determined. As would be expected, substituents in the α position to the keto group influence the rate of racemisation, and it has been found possible to assess the relative electron donating or electron attracting effect of aliphatic, aliphatic-aromatic or aromatic substituents by measuring their influence on the rate of racemisation of a ketone containing the substituent considered.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19600430705
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  • 6
    Electronic Resource
    Electronic Resource
    Über einige β-substituierte Fettsäureamide mit lokalanästhetischer Wirkung. 4. Mitteilung (1959)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 42 (1959), S. 1764-1771 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The preparation and properties of some new β-alkylamino-butyric anilides have been described and a summary report on some of their pharmacological properties is given. Two derivatives (the p-(carbo-n-butoxy)-anilides of β-diethylamino- and of β-(1-piperidino)- butyric acid = XVI and XVIII) show promise as very active local anaesthetics with low toxicities. One derivative (β-N-pyrrolidino-n-butyric acid anilide = XXVII) shows strong potentiation of the sedative properties of barbiturates.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19590420603
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  • 7
    Electronic Resource
    Electronic Resource
    Über einige β-Dialkylaminobuttersäureamide mit anästhetischer Wirkung (1953)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 36 (1953), S. 1698-1705 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The preparation of some β-alkylaminobutyric-acid-amides from the corresponding crotonic acid amides and dimethyl or diethylamine under pressure at 100-150° is described. Two diethylamino acetic acid amides were prepared by reacting N-benzyl-chloracetamide or N-(pethoxybenzyl)-chloracetamide with diethylamine. All these β-dialkyl-aminobutyric and dialkylaminoacetic acid amides show local anaesthetic activity. Two of them (β-diethylaminobutyric acid anilide and β-diethylamino-butyric acid-p-phenetidide) show promise as long acting anaesthetics of low toxicity for nerve block anaesthesia, and are under clinical investigation.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19530360703
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  • 8
    Electronic Resource
    Electronic Resource
    Über die Herstellung und physiologischen Eigenschaften einiger Acetylenverbindungen und verwandter Stoffe. 1. Mitteilung (1953)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 36 (1953), S. 1706-1710 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The preparation of 3-p-methoxyphenyl-1-pentyne-3-ol,3-p-methoxyphenyl-2-pentene-4-yne, 3,4-bis(p-methoxyphenyl)-1-hexyne-3-ol, some reaction products and the physiological properties of these substances are described. 3,4-Bis(p-methoxyphenyl)-hexyne-ol is practically non-toxic and possesses sedative properties.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19530360704
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  • 9
    Electronic Resource
    Electronic Resource
    Über einige β-substituierte Fettsäureamide mit lokalanästhetischer Wirkung. 5. Mitteilung (1959)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 42 (1959), S. 1771-1779 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A further series of butyric acid amides has been synthesised in which the diethylamino, pyrrolidino and piperidino groups of previously reported syntheses have been substituted by morpholino groups. The influence of the various groups in the present and in previously reported derivatives on the pharmacology of the series is reported and summarised. The conditions necessary for maximum local anaesthesia and barbiturate potentiation are discussed.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19590420604
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