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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 784 (1996), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the first assay, tumour-cell suspensions were incubated in Ham's medium with the addition of 15% calf serum, 0.3% agar and rat red blood cells in 17-mm diameter test tubes using a double layer technique. Colonies of 50 cells or more were counted at 28 d and the plating efficiency was 2040%. In ...
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1438-1168
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Zusammenfassung In dieser Arbeit werden Sr, Nd und Pb Isotopendaten transitionaler Basalt-peralkalischer Rhyolithabfolgen und räumlich mit diesen assoziierter kalkalkalischer Rhyolithe der D' Entrecasteaux Inseln im östlichen Papua Neuguinea vorgestellt. Beide Abfolgen zeigen für konvergiernde Plattenränder typische geochemische Signaturen (z.B. hohe Zr/Nb, La/Nb und niedrige Ta/Yb Verhältnisse im Vergleich mit OIB). Die transitionale Basalt-peralkalische Rhyolithabfolge und die kalkalkalischen Rhyolithe zeigen eine geringe Variation in ihren206Pb/204Pb (18.522–18.661),207/204Pb (15.543–15.631) und208Pb/204Pb (38.31–38.63) Verhältnissen, die mit denen von Vulkaniten aus Tonga, Fiji und den pazifischen MOR-Basalten und Sedimenten übereinstimmen. Die transitionale Basalt-peralkalische Rhyolithabfolge zeigt weiters eine geringe Variationsbreite der143Nd/144Nd Verhältnisse (0.513053–0.512984), aber eine größere Streuung der87Sr/86Sr Verhältnisse (0.703989–0.70585). Letztere reflektiern die Unsicherheiten der Alterseinstufung der Proben mit sehr hohen87Rb/86Sr Verhältnissen und die Effekte des Sr-Austausches mit Meerwasser. Die87Sr/86Sr Verhältnisse kalkalkalischer Rhyolithe variieren im Vergleich dazu gerigfügiger (0.703864–0.704028). Isotopen und Spurenelementdaten sind mit der Interpretation, daß die kalkalkalischen Rhyolithe durch partielle Anatexis junger Inselbogen-Protkruste entstanden sind, kompatibel. Die mit ihnen vergesellschafteten basischen bis intermediären klakalkalischen Magmen entstammen einer abgereicherten Mantelquelle, die zuvor durch Subduktionsprozesse entlang des Trobriandgrabens modifiziert wurde. Die transitionale Basalt-peralkalische Rhyolithabfolge entstand durch extensive magmatische Differentiation eines transitionalen basaltischen Stammagmas in einer relativ seicht liegenden Magmenkammer. Das Stammagma wurde durch partielle Aufschmelzung entweder eines abgereicherten MORB-Mantels oder einer weniger stark abgereicherten OIBQuelle, die zuvor durch Subduktionsprozesse modifiziert wurde, gebildet. Die Hyund O1-normativen transitionalen Basaltmagmen wurden wahrscheinlich im Zuge der Ausdünnung von Lithosphäre unter etwas höheren Drucken gebildet als die Quarznormativen kalkalkaischen Magmen. Die enge räumliche und zeitliche Beziehung der transitionalen Basalt-peralkalischen Rhyolithabfolge mit kalkalkalischen Vulkaniten spiegelt die komplexen und dynamischen geotektonischen Vorgänge im östlichen Papua Neuguinea wieder. Der Wechsel von kalkalkalischem zu alkalischem Magmatismus könnte durch die Umstellung von Kompressions- auf Extensionstektonik, die mit der Verlagerung des westlich gelegenen Woodlark Spreadingzenrums in das östliche Papua Neugiunea in Beziehung gebracht wird, erklärt werden.
    Notes: Summary Sr, Nd and Pb isotope data are presented for a transitional basalt-peralkaline rhyolite suite, and spatially associated calc-alkaline rhyolites from the D'Entrecasteaux Islands, eastern Papua New Guinea. Both suites have a typical convergent margin geochemical signature (i.e. high Zr/Nb, La/Nb, and low Ta/Yb compared with OIB). The transitional basalt-peralkaline rhyolite suite and calc-alkaline rhyolites have a restricted range of206Pb/204Pb (18.522–18.661),207Pb/204Pb (15.543–15.631), and208Pb/204Pb (38.31–38.63) values which overlap the fields of volcanics from Tonga, Fiji, and Pacific MORB and sediments. The transitional basalt-peralkaline rhyolite suite also displays a restricted range of143Nd/144Nd values (0.513053–0.512984), but a much broader range of87Sr/86Sr (0.703989–0.70585) values. The latter reflects uncertainties in the ages of samples with very high87Rb/86Sr values and the effects of Sr exchange with seawater. The calc-alkaline rhyolites have consistently lower143Nd/144Nd values (0.512923—0.512867), and a more restricted range of87Sr/86Sr values (0.703864–0.704028) compared with the transitional basalt-peralkaline rhyolite suite. The isotopic and trace element data are consistent with the interpretation that the calc-alkaline rhyolites were produced by partial melting of a young arc protocrust, whereas associated calc-alkaline basic and intermediate magmas were derived from a depleted mantle source which previously had been modified by subduction along the Trobriand Trough. The transitional basalt-peralkaline rhyolite suite was produced by extensive magmatic differentiation of a parental transitional basalt magma in a relatively shallow magma chamber. The parent magma was produced by partial melting of either a depleted MORB-source mantle or a less-depleted OIB-type source which previously had been modified by subduction processes. The hy- and ol-normative transitional basalt magmas were probably generated in response to lithospheric thinning at somewhat higher pressures than qz-normative calc-alkaline magmas. The close spatial and temporal relationship between the transitional basalt-peralkaline rhyolite suite and the tale-alkaline volcanics reflects the complex and dynamic tectonic setting of eastern Papua and the D'Entrecasteaux Islands. In particular, the change from calc-alkaline to alkaline magmatism appears to have occurred following a change from compressional to extensional tectonics resulting from the westward propogation of the Woodlark spreading ridge into eastern Papua.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0819
    Keywords: Key words Explosive volcanism ; Magmatic ; Phreatomagmatic ; Crater Hill ; Basalt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  A series of alternating phreatomagmatic ("wet") and magmatic ("dry") basaltic pyroclastic deposits forming the Crater Hill tuff ring in New Zealand contains one unit (M1) which can only be interpreted as the products of mixing of ejecta from simultaneous wet and dry explosions at different portions of a multiple vent system. The principal characteristics of M1 are (a) rapid lateral changes in the thicknesses of, and proportions in juvenile components in individual beds, and (b) wide ranges of juvenile clast densities in every sample. M1 appears to have been associated with an elongate source of highly variable and fluctuating magma : water ratios and magma discharge rates. This contrasts with the only other documented mixed (wet and dry) basaltic pyroclastic deposits where mixing from two point sources of quite different but stable character has been inferred.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary cis-Diammine-1,1-cyclobutane dicarboxylate platinum II (CBDCA, JM8), an analogue of cisplatin showing reduced toxicity in preclinical studies, was evaluated in 60 patients. Doses were given initially every 3 weeks and escalated from 20 to 520 mg/m2. Following this, doses were given every 4 weeks and escalated from 300 to 500 mg/m2. The dose-limiting toxicity, thrombocytopoenia, occurred in four-fifths of patients treated at 520 mg/m2, with the nadir occurring 3 weeks after treatment. Leucopoenia and anaemia also occurred but were less severe. Vomiting occurred in all patients receiving over 120 mg/m2 but seldom persisted beyond 24 h. Serial measurements of 51Cr-EDTA clearances, urinary N-acetylglucosaminidase, urinary leucine aminopeptidase, and β2-microglobulin did not reveal significant evidence of nephrotoxicity. Detriment to the audiogram has not been seen in the first 13 patients studied. Pharmacological studies showed that most of the dose of platinum was excreted in the urine, and that impairment of renal function may be associated with drug retention and an increased risk of myelosuppression. The previous therapy and age of the patient also affected the tolerance of the drug. Clinical responses were seen in patients with ovarian carcinoma receiving 〉120 mg/m2. A further dose escalation was performed on a 4-week schedule in patients under 65 with good renal function. The maximum dose it was possible to administer repeatedly without incurring myelosuppression was in the range 400–500 mg/m2. JM8 is not significantly nephrotoxic and is less emetic than cisplatin. It has antitumour activity in man and deserves wider evaluation, along with the other analogues under study in various centres, as an alternative to cisplatin.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Cancer chemotherapy and pharmacology 6 (1981), S. 195-196 
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirteen patients with small cell carcinoma of the bronchus that had become resistant to conventional chemotherapy were given 4′-(9-acridinylamino) methanesulphon-m-anisidide (mAMSA) at a dose of 90 or 120 mg/m2 at 3-week intervals. Twenty percent of the courses at 90 mg/m2 produced marked myelosuppression. No responses were observed. Median survival from the start of treatment with mAMSA was 5 weeks.
    Type of Medium: Electronic Resource
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  • 7
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    Sydney : Periodicals Archive Online (PAO)
    The Australian Journal of Anthropology. 9:4 (1974:Dec.) 281 
    ISSN: 1035-8811
    Topics: Ethnic Sciences
    Notes: Cultural Aspects of the Archaeology of the smaller Pacific Islands. Papers from an INQUA Symposium, 1973
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Contributions to mineralogy and petrology 81 (1982), S. 148-155 
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Integration of petrographic and geochemical data on each island in the Banks Group, northern Vanuatu (New Hebrides) has revealed a decrease in K2O (and related incompatible elements) across the islands, away from the New Hebrides trench. The correlation with depth to the Benioff zone is therefore the reverse of that typically found in island arcs. REE evidence and source modelling indicates that this variation represents a progressive depletion in LREE/HREE in the upper mantle, laterally away from the trench and a progressive increase in partial melting of the source, in the same direction. These variations in chemistry are attributed to an earlier west-dipping Miocene subduction system, and the variation in degree of partial melting to the location of the islands with respect to the active back-arc basin. An enrichment of the upper mantle in the Miocene is ascribed to the ascent of hydrous fluids enriched in incompatible elements, from the west-dipping Benioff zone, and subsequent reaction with the overlying upper mantle. The model thus envisages approximately contemporaneous development of the Central Chain volcanoes and the backarc basin in the late Pliocene, with partial melting of hydrous, laterally zoned upper mantle resulting from the convective thermal regime associated with the rifting apart of the back-arc basin. The role of the present subduction regime in magma generation is considered to be very limited.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Eleven patients with advanced adenocarcinoma of lung and six patients with large cell anaplastic carcinoma of lung were treated with combination chemotherapy using cyclophosphamide 1 g/m2 i. v., adriamycin 30 mg/m2 and 5-FU 500 mg/m2 i. v. on days 1 and 8, of a 28 day cycle. In neither group did any patient achieve a complete remission; 1 patient achieved a partial response in each group, and the rest showed no evidence of response. The duration of survival of the responding patients in each group was not significantly longer than those of the non-responders. Toxicity and side effects were considerable in all patients. This study demonstrates that these tumour types are refractory to this form of intensive combination chemotherapy. A literature review suggests that other forms of combination chemotherapy are usually equally ineffective.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study describes the pharmacokinetics of mitoxantrone determined by a sensitive and specific HPLC-method. The time-concentration curves of i.v.-treated patients (15 mg/m2 over 30 min) correspond to a three-compartment model with a T1/2α of 12 min, a T1/2β of 93 min, and a slow elimination phase of 36 h. The central compartment volume was 26.22 and the distribution volume, 1381.9. The mean urinary excretion was 4.9% of the total dose. The pharmacokinetic parameters were also defined in five patients who were treated with combination chemotherapy (mitoxantrone 12 mg/m2, methotrexate 30 mg/m2 and vincristine 2 mg). These results were not different from those with the single-drug treatment, except for the volume of the central compartment, which was significantly decreased. The peak levels after hepatic arterial infusion of mitoxantrone were three times lower than those after the identical dose given i.v. to the same patient. Pleural fluid sampling showed a six-fold increase compared with the plasma level (12 ng/ml versus 2 ng/ml). A multiple linear regression analysis of the data revealed correlations between the pharmacokinetic results and some of the baseline parameters. It is possible to predict changes in the kinetic behaviour of mitoxantrone on the basis of these relations but on the other hand toxicity is less predictable from the baseline parameters or from the pharmacokinetic results.
    Type of Medium: Electronic Resource
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