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  • 1
    Electronic Resource
    Electronic Resource
    The treatment of flexion contracture of the knee using the Ilizarov technique in a child with haemophilia B (2003)
    Oxford, UK : Blackwell Science Ltd
    Haemophilia 9 (2003), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary.  Severe factor IX deficiency is an X-linked disorder which gives rise to spontaneous and often life-threatening bleeds. The major source of morbidity worldwide is recurrent haemarthroses, giving rise to joint destruction and deformity. However, the incidence of spontaneous haemarthroses has decreased since the advent of prophylactic home-based, on-demand, early replacement therapy.We present the case of a non-ambulant, 13-year-old boy from Chernobyl, who did not have access to this type of treatment, and whose deformity was managed using the Ilizarov external fixator.An external fixator was applied under general anaesthetic in theatre. Haemostasis was achieved by maintaining his FIX levels at 1.0 IU mL−1 pre- and post-operatively. Three months later, the fixed flexion deformity had been reduced from 50 to 5°. Four months postsurgery, this boy was walking freely without pain. There was no peri- or post-operative bleeding or joint swelling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2516.2003.00753.x
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  • 2
    Electronic Resource
    Electronic Resource
    Efficacy of a high purity, chemically treated and nanofiltered factor IX concentrate for continuous infusion in haemophilia patients undergoing surgery (1999)
    Oxford UK : Blackwell Science Ltd
    Haemophilia 5 (1999), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have evaluated the haemostatic efficacy of plasma derived, highly purified, solvent-detergent treated factor IX concentrate (Nanotiv®), to which a nanofiltration step has recently been added to improve safety with regard to parvovirus B19, hepatitis A and other nonlipid enveloped viruses. Thirteen surgical procedures, including eight orthopaedic operations, were carried out using continuous infusion of Nanotiv in 10 haemophilia B patients (nine severe and one mild). Tranexamic acid was used for 11 of the 13 procedures. The mean factor IX levels on the day of surgery and postoperative days 1–3 were 0.77, 0.89, 0.80 and 0.73 IU mL–1, respectively. The haemostatic effect was rated as normal or excellent and no blood transfusions were needed. One patient had thrombophlebitis twice at the infusion site. The remaining cases received heparin, 5 units per 100 IU of Nanotiv, and had neither superficial nor deep venous thromboembolic complications. The requirement for factor IX in the four joint replacement operations was 663 IU kg–1 during the first 9 days, which compares favourably with previous materials. Thus, continuous infusion with this highly purified factor IX concentrate with improved viral safety is effective for surgery in haemophilia B.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2516.1999.t01-1-00284.x
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  • 3
    Electronic Resource
    Electronic Resource
    Randomized comparison of unfractionated heparin with corticosteroids in severe active inflammatory bowel disease (2000)
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 14 (2000), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Heparin therapy may be effective in steroid resistant inflammatory bowel disease.〈section xml:id="abs1-2"〉〈title type="main"〉Aim:A randomized pilot study, to compare unfractionated heparin as a first-line therapy with corticosteroids in colonic inflammatory bowel disease.〈section xml:id="abs1-3"〉〈title type="main"〉Methods:Twenty patients with severe inflammatory bowel disease (ulcerative colitis, n=17; Crohn’s colitis, n=3) were randomized to either intravenous heparin for 5 days, followed by subcutaneous heparin for 5 weeks (n=8), or high-dose intravenous hydrocortisone for 5 days followed by oral prednisolone 40 mg daily, reducing by 5 mg per day each week (n=12). After 5 days, non-responders in each treatment group were commenced on combination therapy. Response to therapy was monitored by: clinical disease activity (ulcerative colitis: Truelove and Witt Index; Crohn’s colitis: Harvey and Bradshaw Index), stool frequency, serum C-reactive protein and α1 acid glycoprotein, endoscopic and histopathological grading.〈section xml:id="abs1-4"〉〈title type="main"〉Results:The response rates were similar in both treatment groups: clinical activity index (heparin vs. steroid; 75% vs. 67%; P=0.23), stool frequency (75% vs. 67%; P=0.61), endoscopic (75% vs. 67%; P=0.4) and histopathological grading (63% vs. 50%; P=0.67). Both treatments were well-tolerated with no serious adverse events.〈section xml:id="abs1-5"〉〈title type="main"〉Conclusion:Heparin as a first line therapy is as effective as corticosteroids in the treatment of colonic inflammatory bowel disease. Large multicentre randomized comparative studies are required to determine the role of heparin in the management of inflammatory bowel disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2000.00802.x
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  • 4
    Electronic Resource
    Electronic Resource
    Nucleotide sequence andE. coli expression of the coat protein gene of the yellowing strain of soybean dwarf luteovirus (1993)
    Springer
    Archives of virology 133 (1993), S. 223-231 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The nucleotide sequence of the coat protein gene of the yellowing (Y) strain of soybean dwarf virus (SbDV) was determined from cloned cDNA. The gene contains 600 nucleotides and encodes a protein of 200 amino acids with a calculated Mr of 22 200. The identity of the open reading frame (ORF) encoding the coat protein was confirmed by expression of anEscherichia coli β-galactosidase fusion protein and detection by a dot blot immunoassay. Sequence comparisons of the deduced coat protein amino acids to several luteoviruses demonstrated that the SbDV-Y coat protein ORF shares greatest similarity with bean leaf roll virus (BLRV) (65%).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01309758
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  • 5
    Electronic Resource
    Electronic Resource
    Cultivar differences in the expression of potato leaf spotting disorder in Maine (1986)
    Springer
    Potato research 29 (1986), S. 313-319 
    Details
    ISSN: 1871-4528
    Keywords: Solanum tuberosum ; speckle-bottom disease ; speckle-leaf ; air pollution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Zusammenfassung Zehn Kartoffelsorten wurden an drei Standorten in Maine in jeweils zwei Jahren hinsichtlich der Höhe des Schadens durch Blattflecken untersucht. Zwischen den Sorten (Tabellen 1 und 2) und den Standorten (Tabellen 2, 3 und 4) wurden gleichbleibende Unterschiede bei der Blattfleckung gefunden. Die Unterschiede drückten sich von ‘frei von Blattflecken’ bei der Sorte ‘Seminole’ bis zu 80% Flecken bei der Sorte ‘Plymouth’ aus (Tabelle 1). Diese Blattfleckung unterscheidet sich von der Schädigung durch Luftverschmutzung durch die Entwicklung von Symptomen zuerst auf der Blattoberfläche (Hooker et al., 1973). Bodenanalysen bei den drei verschiedenen Standorten zeigten, dass der Standort mit der höchsten Blattfleckung den höchsten Gehalt an Phosphor und den niedrigsten Gehalt an Eisen und Aluminium aufwies (Tabellen 3 und 4). Obwohl die Einflüsse anderer Elemente nicht ausgeschlossen werden konnten, ist anzunehmen, dass die Einflüsse von Eisen-, Aluminium-und Phosphorgehalten auf die Ätiologie dieser Krankheit die aussichtsreichsten Gebiete für weitere Untersuchungen sind.
    Abstract: Résumé Dix variétés de pommes de terre sont classées quant à l'expression d'anomalies foliaires en taches, dans trois localités pendant deux années, dans le Maine. Des différences conséquentes sont observées entre les variétés (tableaux 1 et 2) et entre les localités (tableaux 2, 3, et 4). Les différences varient de: aucune tache pour la variété ‘Seminole’ à 80% de taches pour ‘Plymouth’ (tableau 1). Les anomalies foliaires en taches sont distinguées des lésions dues à la pollution atmosphérique par l'apparition primaire des symptômes sur la face inférieure des feuilles (Hooker et al., 1973). Les analyses de sol des trois localités montrent que les symptômes les plus marqués sont observés dans la localité ayant les plus hauts niveaux de phosphore et les plus faibles de fer et d'aluminium (tableaux 3 et 4). Bien que les effets des autres éléments ne puissent pas être écartés, il semble que les meilleures voies de recherches futures soient les effets des niveaux d'aluminium, de fer et de phosphore sur l'étiologie de cette anomalie.
    Notes: Summary Ten potato cultivars were rated for a leaf spotting disorder at three locations in Maine in each of two years; there were consistent differences between cultivars and between locations. Cultivar Seminole had no symptoms but cultivar Plymouth had severe symptoms in both years. A comparison of preliminary data of soil analyses and leaf spotting scores for the three locations showed that higher levels of the disorder were associated with higher levels of phosphorous and lower levels of aluminum and iron. The effects of nitrogen and other elements on leaf spotting could not be discounted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02359960
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