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  • 1
    Electronic Resource
    Electronic Resource
    Inhibition of cholinesterase by 1,3,2-dioxaphosphorinane 2-oxide derivatives (1972)
    s.l. : American Chemical Society
    Biochemistry 11 (1972), S. 3518-3523 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00769a004
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  • 2
    Electronic Resource
    Electronic Resource
    Iron, Mild Steels, and Low Alloy Steels (1948)
    s.l. : American Chemical Society
    Industrial & engineering chemistry 40 (1948), S. 1798-1800 
    Details
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ie50466a014
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  • 3
    Electronic Resource
    Electronic Resource
    Iron, Mild Steels, and Low Alloy Steels (1949)
    s.l. : American Chemical Society
    Industrial & engineering chemistry 41 (1949), S. 2122-2124 
    Details
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ie50478a017
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  • 4
    Electronic Resource
    Electronic Resource
    Iron Mild Steels and Low-Alloy Steels (1950)
    s.l. : American Chemical Society
    Industrial & engineering chemistry 42 (1950), S. 1986-1990 
    Details
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ie50490a012
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  • 5
    Electronic Resource
    Electronic Resource
    Enthalpy probe performance in compressible thermal plasma jets (1993)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 64 (1993), S. 3585-3593 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Enthalpy probe measurements in compressible argon/helium thermal plasma jets are compared with results from high spectral resolution laser light scattering. In the laser scattering measurement the plasma temperature and velocity are determined directly from high-resolution line-shape analysis of light scattered by the plasma. The technique yields an unambiguous determination of gas or kinetic temperature without the assumption of local thermodynamic equilibrium. Velocity is determined directly from the measured Doppler shift. The enthalpy probe is a combination stagnation probe and flowing calorimeter. Gas temperatures and velocities are calculated from measured values using both frozen flow and equilibrium flow assumptions for the stagnation process. Over the Mach number range examined, the assumption of isentropic, frozen composition stagnation best matches the laser results. In the jet periphery a significant streamline displacement is caused by the presence of the probe. The displacement, which is a function of the nondimensional radial velocity gradient, distorts the velocity and temperature results in the wings of the profiles. In the core of the jets examined, probe measurements in both subsonic and supersonic compressible flows show excellent agreement with laser scattering results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1144285
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  • 6
    Electronic Resource
    Electronic Resource
    Comparison of enthalpy probe and laser light scattering measurement of thermal plasma temperatures and velocities (1993)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 64 (1993), S. 711-718 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Gas temperature and velocity profiles in argon thermal plasmas, measured by an enthalpy probe and high spectral resolution laser light scattering, are compared. In the laser scattering measurement the plasma temperature and velocity are determined directly from high-resolution Doppler-shifted line-shape analysis of light scattered by the plasma. The technique yields an unambiguous determination of gas or kinetic temperature without the assumption of local thermodynamic equilibrium. Velocity is determined directly from the measured Doppler shift. The enthalpy probe is a combination Pitot tube and flowing calorimeter. The assumption of thermodynamic equilibrium is required to obtain velocity and temperature from measured enthalpy and stagnation pressure. Peak temperature and velocity values observed were ∼13 000 K and 1300 m s−1. The results from both the intrusive enthalpy probe and nonintrusive laser light scattering technique compare favorably. The limitations of both techniques are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1144203
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  • 7
    Electronic Resource
    Electronic Resource
    HIGH AFFINITY TRANSPORT OF CHOLINE INTO SYNAPTOSOMES OF RAT BRAIN (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 21 (1973), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: —The accumulation of [3H]choline into synaptosome-enriched homogenates of rat corpus striatum, cerebral cortex and cerebellum was studied at [3H]choline concentrations varying from 0.5 to 100 μm. The accumulation of [3H]choline in these brain regions was saturable. Kinetic analysis of the accumulation of the radiolabel was performed by double-reciprocal plots and by least squares iterative fitting of a substrate-velocity curve to the data. With both of these techniques, the data were best satisfied by two transport components, a high affinity uptake system with Km. values of 1.4 μM (corpus striatum), and 3.1 μM (ceμ(cerebral cortex) and a low affinity uptake system with respective Km. values of 93 and 33 μM for these two brain regions. In the cerebellum choline was accumulated only by the low affinity system. When striatal homogenates were fractionated further into synaptosomes and mitochondria and incubated with varying concentrations of [3H]choline, the high affinity component of choline uptake was localized to the synaptosomal fraction. The high affinity uptake system required sodium, was sensitive to various metabolic inhibitors and was associated with considerable formation of [3H]acetylcholine. The low affinity uptake system was much less dependent on sodium, and was not associated with a marked degree of [3H]acetylcholine formation. Hemicholinium-3 and acetylcholine were potent inhibitors of the high affinity uptake system. A variety of evidence suggests that the high affinity transport represents a selective accumulation of choline by cholinergic neurons, while the low affinity uptake system has some less specific function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1973.tb06022.x
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  • 8
    Electronic Resource
    Electronic Resource
    AMINO ACIDS AS CENTRAL NERVOUS TRANSMITTERS: THE INFLUENCE OF IONS, AMINO ACID ANALOGUES, AND ONTOGENY ON TRANSPORT SYSTEMS for l-GLUTAMIC AND l-ASPARTIC ACIDS AND GLYCINE INTO CENTRAL NERVOUS SYNAPTOSOMES OF THE RAT (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 21 (1973), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: —The accumulation by synaptosomal fractions from rat central nervous system tissue of transmitter candidate amino acids and non-candidate amino acids was studied with respect to ionic requirements, metabolic inhibitors, structural analogues, and ontogeny. For l-glutamic and l-aspartic acids in cortex and spinal cord and glycine in spinal cord a stringent sodium requirement for high affinity uptake was demonstrated. Detailed kinetic analysis of the sodium requirement for glutamic acid uptake into cortical synaptosomal fractions suggests that: (1) sodium ion acts both competitively and non-competitively in determining the velocity of high affinity uptake; (2) in the absence of sodium ion only the low affinity uptake can be demonstrated; and (3) inhibition of the Na–K-ATPase enzyme system with ouabain reduces the velocity of uptake to 60% of control values in contrast to alanine whose synaptosomal uptake is less dependent on this enzyme system. No potent inhibitors of l-glutamic acid accumulation were found among several structural analogues or derivatives. The kinetic analysis for glycine accumulation was more complex and suggested allosteric interactions between glycine and sodium ion. Developmental studies revealed GABA and l-glutamic acid to have absolute sodium requirements for cortical synaptosomal accumulation from the 16th gestational day through adulthood, with glycine accumulation showing a decreasing sodium requirement as maturation proceeded over this period. The combined evidence suggests that sodium requirement for high affinity uptake is a characteristic of neuroactive substances and may be used as a screening tool to search for other neurotransmitter candidates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1973.tb06037.x
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  • 9
    Electronic Resource
    Electronic Resource
    THE SUBCELLULAR LOCALIZATION OF HISTAMINE AND HISTAMINE METHYLTRANSFERASE IN RAT BRAIN (1971)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 18 (1971), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— We have examined the subcellular localization of histamine and histamine methyl-transferase (S-adenosylmethionine: histamine 7V-methyltransferase; EC 2.1.1.8) in rat brain. The highest levels of histamine and histamine methyltransferase activity were found in the hypothalamus. A large proportion of hypothalamic histamine and histamine methyltransferase activity was found in particles with sedimentation properties in sucrose gradients similar to synaptosomes storing norepinephrine and serotonin. Histamine displayed a bimodal distribution in sucrose gradients. A substantial amount of a tracer dose of [3H]histamine added to hypothalamic homogenates at 4°C was bound to particulate fractions, suggesting that endogenous histamine may redistribute and bind to subcellular fractions during homogenization. The second, lighter peak of histamine in sucrose gradients was thought to be due to histamine that redistributed during homogenization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1971.tb00014.x
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  • 10
    Electronic Resource
    Electronic Resource
    GABA Receptor binding in frog spinal cord and brain (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 28 (1977), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1977.tb10639.x
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