Electronic Resource
Springer
The European physical journal
35 (2003), S. 117-123
ISSN:
1434-6036
Source:
Springer Online Journal Archives 1860-2000
Topics:
Physics
Notes:
Abstract. The dynamics of cancer evolution is studied by means of a simple quasispecies model involving cells displaying high levels of genetic instability. Both continuous, mean-field and discrete, bit-string models are analysed. The string model is simulated on a single-peak landscape. It is shown that a phase transition exists at high levels of genetic instability, thus separating two phases of slow and rapid growth. The results suggest that, under a conserved level of genetic instability the cancer cell population will be close to the threshold level. Implications for therapy are outlined.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1140/epjb/e2003-00262-8
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