ISSN:
1546-1718
Source:
Nature Archives 1869 - 2009
Topics:
Biology
,
Medicine
Notes:
[Auszug] We report germline loss-of-function mutations in SPRED1 in a newly identified autosomal dominant human disorder. SPRED1 is a member of the SPROUTY/SPRED family of proteins that act as negative regulators of RAS-〉RAF interaction and mitogen-activated protein kinase (MAPK) signaling. The clinical ...
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1038/ng2113
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