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  • 1
    Electronic Resource
    Electronic Resource
    Notch signalling controls pancreatic cell differentiation (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 400 (1999), S. 877-881 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The pancreas contains both exocrine and endocrine cells, but the molecular mechanisms controlling the differentiation of these cell types are largely unknown. Despite their endodermal origin, pancreatic endocrine cells share several molecular characteristics with neurons, and, like neurons in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/23716
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Embryonic gene expression resolved at the cellular level by fluorescence in situ hybridization (1999)
    Springer
    Histochemistry and cell biology 111 (1999), S. 435-443 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  Tyramide signal amplification has successfully been applied to enhance detection limits of both immunological reactions and in situ hybridization methods. The technique uses short-range deposition of activated tyramide mediated by horseradish peroxidase. We have adapted this method to fluorescence in situ hybridization on embryonic tissue sections using fluorophore-labeled tyramide. The sensitivity of the procedure was sufficient to analyze the embryonic expression of mRNAs encoding both transcription factors and structural proteins. Combining fluorescence in situ hybridization and immunofluorescence with confocal microscopy allows the simultaneous detection of distinct mRNA species or of mRNAs together with proteins on the cellular level. Thus, the cell types expressing a particular gene at a given developmental stage can be studied even if no antibody to the gene product of interest is available. Moreover, the technique allows to study in situ the combinatorial marker expression that characterizes progenitor stages of a given cell lineage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004180050379
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The glycoprotein P0 in peripheral gliogenesis (1998)
    Springer
    Cell & tissue research 292 (1998), S. 11-16 
    Details
    ISSN: 1432-0878
    Keywords: Key words Protein zero ; Peripheral gliogenesis ; Neural crest ; Myelination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  Recent data show that during development protein zero, P0, the most abundant peripheral nerve myelin protein, is detecable long before myelination. In particular, the expression of P0 in a fraction of migrating neural crest reveals progenitor cell heterogeneity in the developing PNS. Here we review the regulation and potential function of P0 during peripheral gliogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004410051029
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    Paper (German National Licenses)
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