ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Abstract: Using magnetic resonance methods and a clinically relevantrodent model of sepsis, we have made in vivo measurements of increasedintracellular calcium in a pathologic state in the CNS. The intracellularcalcium concentration was increased nearly twofold in septic rat braincompared with controls (p 〈 0.0001). This result, in a fullyintact functioning mammalian system, ties together a previous spectrum ofindirect evidence from numerous laboratories suggesting an important role forelevated intracellular calcium in sepsis. In addition, levels of theproinflammatory cytokine tumor necrosis factor-α were elevated threefoldin septic rat brain (p 〈 0.02), and electron microscopic examination revealed scattered injury in ∼0.25% of glial cells. These findings are discussed in light of the current understanding of the pathophysiology of sepsis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1046/j.1471-4159.1999.0722617.x
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