ISSN:
0941-1216
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Conformation and Rotation Barriers of Substituted Glyoxylic Acid AmidesSemiempirical calculations predict an orthogonal orientation of the carbonyl groups in tertiary glyoxylic acid amides, which is in good agreement with an X-ray structure analysis of 5. Due to the influence of the α-carbonyl group, the rotation barrier in the substituted glyoxylic acid amides 2a-d, 3a, 3b, and 4-6 (ΔG#c = 84-92 kJ mol-1) is about 10 kJ/mol higher than in simple acid amides, as was found by dynamic NMR line shape analysis.
Additional Material:
2 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/prac.19973390143
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