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  • 1
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 73 (1993), S. 4955-4970 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The morphological instability of a growing epitaxially strained dislocation-free solid film is analyzed. An evolution equation for the film surface is derived in the dilute limit of vacancies based on surface diffusion driven by a stress-dependent chemical potential. From the time-dependent linear stability problem the conditions for which a growing film is unstable are determined. It is found that the instability is driven by the lattice mismatch between the film and the substrate; however, low temperatures as well as elastically stiff substrates are stabilizing influences. The results also reveal that the critical film thickness for instability depends on the growth rate of the film itself. Detailed comparison with experimental observations indicates that the instability described exhibits many of the observed features of the onset of the "island instability.''
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of interventional cardiology 4 (1991), S. 0 
    ISSN: 1540-8183
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of interventional cardiology 12 (1999), S. 0 
    ISSN: 1540-8183
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Restenosis after balloon angioplasty remains a substantial clinical problem. Endovascular radiation has been shown to reduce neointima formation in animal models of restenosis, and the results of early clinical trials are promising. However, this technique has several limitations, particularly, the inability to delay or fractionate therapy and inhomogeneous dose distribution. These shortcomings might be overcome by delivering radiation therapy from an external approach. This study investigated the effects of high dose external beam irradiation on balloon-injured pig coronary arteries. Methods and Results: Eight domestic juvenile pigs underwent balloon overstretch injury. External beam irradiation (21 Gy) of the heart was performed within 2 hours on four pigs and the remainder were not irradiated (controls). Sections of paraffin embedded injured arteries, perfusion fixed at 4 weeks, were measured by computer-assisted histomorphometry. Luminal area in the 21-Gy group was 3.84 ± 1.80 mm2 compared to 2.0 4 ± 0.49 mm2 in the controls (P 〈 0.01). Neointimal area and maximal intimal thickness were reduced in the 21-Gy group (0.23 ± 0.36 vs 1.36 ± 0.67mm2, P 〈 0.0005; 0.25 ± 0.35 vs 0.64 ± 0.2, P 〈 0.01, respectively). Diffuse focal interstitial fibrosis was observed in the myocardium of the irradiated group. Conclusions: At 21 Gy, external beam irradiation significantly increased lumen size and reduced neointima formation in balloon-injured pig coronary arteries. However, myocardial damage was also induced by irradiation of the whole heart at this dose.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1540-8183
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Vascular constriction post PTCA is a major component in the mechanism of restenosis following intervention. Ionizing radiation demonstrated reduction of neointima formation after injury in animal models and lowered the restenosis rates in pilot clinical studies. To determine the effect of intracoronary radiation therapy on vascular remodeling, angiograms from two radiation trials were analyzed by QCA methods. Patients in these trials had de novo lesions and were treated with balloon angioplasty followed by either beta or gamma radiation. All patients were studied angiographically at 6 months; patients with total occlusion at the treated artery were excluded from the analysis. In the gamma trial, 192-Iridium was utilized in 14 patients (15 lesions) with doses between 20-25 Gy. In the beta trial, 90-Sr/Y was utilized in 17 patients (17 lesions) with doses between 12-16 Gy. The QCA analysis from these studies demonstrated negative late loss and late loss index at six months for patients from the beta (-0.02 ± 0.3) and the gamma (-0.19 ± 0. 3) study. The effect of positive remodeling was maintained at 24 months, -0.16 ± 0.4 in the gamma group. Larger MLD at follow-up compared to the immediate post MLD were demonstrated in 50% of the patients from both studies. Thus, intracoronary radiation resulted in lower late loss and late loss index rates than previously reported following balloon angioplasty alone suggesting a positive vascular remodeling effect of intracoronary radiation.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 86 (1999), S. 5530-5536 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The equilibrium shape and chemical potential of an array of island ridges in an epitaxially strained solid film are determined from a continuum model describing the Stranski–Krastonow morphology of a thin layer on a substrate. This model incorporates the conditions for mechanical and chemical equilibrium, isotropic surface energy, and misfit strain. Solutions corresponding to periodic arrays of island ridges separated by wetting layers are found in the limit of island height much less than the island width. Our results describe how the island width, shape, and chemical potential vary as the distance between the ridges varies. The scaled island shape is shown to remain relatively constant as the distance between the islands increases. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial and engineering chemistry 23 (1984), S. 432-436 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 76 (2000), S. 3022-3024 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We analyze the development of compositional and surface nonuniformities during the growth of strained alloy films, for the case of different surface mobilities of the alloy components. We find that a difference in surface mobilities can completely suppress the stress-driven morphological instability. The stabilization occurs under compressive misfit when one atomic species is both large and fast relative to the other, and similarly under tensile misfit when one species is small and fast. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 77 (2000), S. 2533-2535 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We calculate (to first order in the Burgers vector) the energy of introducing dislocations into Stranski-Krastanow islands having equilibrium shape. These results suggest that misfit dislocations of different Burgers vector tend to segregate spatially within the islands, which may be a source of mosaic structure in films formed by island coalescence. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 104 (1982), S. 1882-1893 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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