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  • 1
    Electronic Resource
    Electronic Resource
    Raman Spectra. Hydrocarbons and Oxygenated Compounds (1950)
    s.l. : American Chemical Society
    Analytical chemistry 22 (1950), S. 1074-1114 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60045a002
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Faulty Flying Machine (1972)
    [s.l.] : Nature Publishing Group
    Nature 240 (1972), S. 309-309 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR,-I believe your readers would be concerned to hear of the unfortunate fate of a colleague who constructed a flying machine based upon a design of H. C. Bennet-Clark (Nature, 239, 451 ; 1972). The machine became airborne satisfactorily but when adjusting the trim to change from a subsonic to a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/240309a0
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  • 3
    Electronic Resource
    Electronic Resource
    A randomised cross-over trial of megestrol acetate vs tamoxifen as initial treatment for post-menopausal women with advanced breast cancer
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 28 (1987), S. 102 
    Details
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4731(87)91399-9
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  • 4
    Electronic Resource
    Electronic Resource
    Phase II studies of ifosfamide alone and in combination in cancer of the cervix (1990)
    Springer
    Cancer chemotherapy and pharmacology 26 (1990), S. S12 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A series of phase II studies using ifosfamide (IFX) as a single agent and in combination with cisplatin and bleomycin (BIP) in advanced and recurrent cervical cancer have been coordinated at the West Midlands CRC Clinical Trials Unit (Birmingham, UK). The aims of these studies were to identify single agents and combination regimens that may be of value for palliation and have potential for use as neoadjuvant and adjuvant therapy at the time of primary treatment. A total of 79 patients with disease non-amenable to radical local therapy were treated with single-agent IFX or the BIP combination. In 30 patients treated with single-agent IFX, 10 objective responses (30%) were seen, with 1 complete response. In 49 patients treated with BIP, 34 objective responses (69%) were seen, with 10 complete responses (20%). Toxicity included alopecia, nausea and vomiting, myelosuppression, infection, reduction in renal function and disturbance of consciousness. These data indicate that IFX is highly active in cervix cancer and, in combination with bleomycin and cisplatin, can be used for effective palliation and cytoreduction in 〉70% of patients. IFX-containing regimens have potential for use as neoadjuvant and adjuvant therapy in patients at high risk of recurrence with conventional treatment. These hypotheses are currently being tested in prospective randomised trials.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685409
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  • 5
    Electronic Resource
    Electronic Resource
    A reassessment of site suitability analysis for power plant siting: a Maryland example
    Amsterdam : Elsevier
    Applied Geography 7 (1987), S. 223-241 
    Details
    ISSN: 0143-6228
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Geography
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0143-6228(87)90035-X
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  • 6
    Electronic Resource
    Electronic Resource
    Quinacillin: A New Penicillin With Unusual Properties (1963)
    [s.l.] : Nature Publishing Group
    Nature 199 (1963), S. 354-356 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A CYLATION of 6-aminopenicillanic acid (6-APA)1JL has provided a number of clinically effective, semi-synthetic penicillins2 some of which are resistant to hydrolysis by staphylococcal penicillinase. In the course of a programme concerned mainly with heterocyclic side-chain penicillins, we noted at ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/199354a0
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  • 7
    Electronic Resource
    Electronic Resource
    Neoadjuvant bleomycin, ifosfamide and cisplatin in cervical cancer (1990)
    Springer
    Cancer chemotherapy and pharmacology 26 (1990), S. S59 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Patients with advanced and bulky early-stage cancer of the cervix have an unfavourable prognosis, which may be improved by initial neoadjuvant, cytoreductive chemotherapy. In a phase II study, coordinated at the West Midlands CRC Clinical Trials Unit, Birmingham, using ifosfamide (IFX) in combination with cisplatin and bleomycin (BIP) in advanced and recurrent cervical cancer, we demonstrated a response rate of 69%. This regimen produces rapid responses with acceptable toxicity and has potential for use as neoadjuvant therapy prior to radical radiotherapy in patients presenting with advanced and bulky early-stage disease. In an initial pilot study of this approach, 13 of 19 patients (68%) with primary inoperable disease showed significant tumour regression prior to radical local radiotherapy. Interim analysis of the first 66 patients entered into a randomized study evaluating the value of this approach has shown complete clinical tumour resolution after radical radiotherapy in 24/32 patients (75%) treated with up to three cycles of BIP prior to radiotherapy vs 19/34 patients (56%) treated with radiotherapy alone. There was no evidence that neoadjuvant chemotherapy enhances the acute toxic effects of pelvic radiotherapy. This approach has the potential for improving the outlook in patients with poor-prognosis primary disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685422
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  • 8
    Electronic Resource
    Electronic Resource
    Surgical management of vertebral neoplasia: Who, when, how and why? (1994)
    Springer
    European spine journal 3 (1994), S. 342-346 
    Details
    ISSN: 1432-0932
    Keywords: Spinal surgery ; Neoplasia ; Metastasis ; Decompression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To determine the role of surgery in vertebral neoplasia, we conducted a retrospective review of patients undergoing surgery for vertebral neoplasia in the Royal Orthopaedic Hospital, Birmingham, and Coventry and Warwickshire Hospital, Coventry. Surgery included decompression, stabilisation or both. The neurological status was assessed by Frankel grading before and after surgery. Of 70 patients undergoing surgery, 14 were neurologically intact preoperatively, and a further 25 were weak but ambulatory. Following surgery, 35 were intact, and a further 22 were ambulatory. Sixty-six patients (94%) obtained good pain relief. Survival correlated with histology and younger age at presentation, but not with level, neurology at presentation or type of surgery. We conclude that neurological status, pain relief and mechanical stability are better after appropriate surgery than after radiotherapy or inappropriate surgery. Failure to consider the surgical option may deny the chance of significant neurological recovery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02200148
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  • 9
    Electronic Resource
    Electronic Resource
    Phase II clinical trials of cisplatin-then-paclitaxel and paclitaxel-then-cisplatin in patients with previously untreated advanced epithelial ovarian cancer (2000)
    Springer
    Annals of oncology 11 (2000), S. 1603-1608 
    Details
    ISSN: 1569-8041
    Keywords: cisplatin ; ovarian cancer ; paclitaxel ; sequential chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose:To examine the activity and safety of two sequentiallyscheduled chemotherapy regimens comprising four cycles of paclitaxel (pctx)200 mg/m2/3 hours then four cycles of cisplatin (cisDDP) 100mg/m2, and vice versa, in patients with previouslyuntreated advanced ovarian cancer. Patients and methods:Between January 1994 and February 1996, werecruited 30 patients to the pctx-then-cisDDP regimen and 29 tocisDDP-then-pctx, in parallel phase II trials. Results:Both regimens were predictably active with responses seenin 22 of 30 patients (OR 74%; CR 27%, PR 47%) treatedwith pctx-then-cisDDP, as against 13 of 21 patients (OR 62%; CR38%, PR 24%) treated with cisDDP-then-pctx. The OR rate to fourcycles of pctx (induction) was 43%, with 27% diseaseprogression; the OR to four cycles of cisDDP (induction) was 57%, with5% progression. However, progression rates across both induction andconsolidation phases were 16% (pctx-then-cisDDP) and 29%(cisDDP-then-pctx). Both regimens were unacceptably neurotoxic, 11 patientssuffering grade 3 sensory neurotoxicity (5 on pctx-then-cisDDP, 6 oncisDDP-then-pctx) and 20 having grade 3 deafness (9 on pctx-then-cisDDP, 11on cisDDP-then-pctx). Conclusion:The activity of these sequential regimens justifiestheir further development using the less neurotoxic platinum analoguecarboplatin, perhaps combining paclitaxel with other platinum non-crossresistant drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008343519687
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  • 10
    Electronic Resource
    Electronic Resource
    RFLP analysis of the wild potato species, Solanum acaule Bitter (Solanum sect. Petota) (1992)
    Springer
    Theoretical and applied genetics 84 (1992), S. 851-858 
    Details
    ISSN: 1432-2242
    Keywords: Solanum acaule ; Intraspecific variation ; RFLP ; Principal component analysis ; Potato
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Intraspecific variation of a wild potato species, Solanum acaule Bitt., was analyzed by RFLPs of genomic DNA. One hundred and five accessions were selected throughout the distribution area, including all subspecies, i.e., ssp. albicans (hexaploid), ssp. punae (tetraploid), ssp. acaule (tetraploid) and ssp. aemulans (tetraploid). Twenty-seven low-copy DNA clones (probes) were Southern hybridized with EcoRI, EcoRV, HindIII, and XbaI digests of total DNA of all accessions. In total, 238 RFLPs were detected from 94 enzyme x probe combinations. Among them, 49 RFLPs were specific to ssp. albicans, suggesting that the additional third genome is distinct from its two other genomes. RFLPs between and within subspecies were analyzed by principal component analysis. DNA similarities between subspecies coincided with a former taxonomic treatment in the sense that ssp. albicans is the most distantly related to ssp. acaule and ssp. aemulans is distantly related. Subspecies acaule and ssp. punae were indistinguishable. In addition, RFLPs could be used to distinguish groups within subspecies. Subspecies aemulans, confined to Argentina, was divided into two populations, one from the province of La Rioja and the other from the province of Jujuy. In ssp. acaule, some accessions from the southernmost distribution area were clearly distinguishable, while the others varied continuously, showing a geographical cline from Peru to Argentina.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227396
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