ISSN:
1432-1432
Keywords:
G protein α subunit
;
Molecular phylogeny
;
Nucleotide substitution
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary Rooted phylogenetic trees for a total of 34 genes encoding the stimulatory (sα), inhibitory (iα), transducin (tα), Gx (xα), Gz (zα), G11 (α11), G12 (α12), G13 (α13), G16 (α16), Gq (qα), and other (oα) G protein a subunits have been constructed. The analysis shows that the G12 (α12 and α13), Gq (α11, α16, and qα), and Gs (sα genes) groups form one cluster, and the Gx (xα and zα genes), Gi (iα genes), Gt (tα1 and tα2), and Go (oα genes) groups form another cluster. During mammalian evolution, the rates of synonymous substitutions for these genes were estimated to be between 1.77 × 10−9/site/year and 5.63 × 10−9/site/year, whereas those of nonsynonymous substitutions were between 0.008 × 10−9/site/year and 0.067 × 10−9/site/year. These evolutionary rates are similar to those for histone genes, suggesting equally important biological functions of the G protein a subunits.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00178599
Permalink