ISSN:
1573-8221
Keywords:
mitochondria
;
cytochrome oxidase
;
succinate dehydrogenase
;
malignant transformation
;
thyroid gland
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Activity of cytochrome oxidase and succinate dehydrogenase in the mitochondria of thyroid gland cells of rats was studied by electron-histochemical and morphometric methods during experimental carcinogenesis. The activity of these enzymes in the mitochondria was shown to vary depending on the stage of malignant transformation: In the early stages it was close to normal, but later (precancer) it fell sharply and approached the level observed in the mitochondria of cancer cells. A marked decrease in the activity of the enzymes studied in the morphologically altered mitochondria of cancer cells may be a qualitative characteristic of these cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00807498
Permalink