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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK and Boston, USA : Blackwell Publishers Ltd
    Corporate governance 8 (2000), S. 0 
    ISSN: 1467-8683
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Political Science , Economics
    Notes: On May 7, 1998, at a press conference in London that had been called on very short notice, the CEOs of Daimler-Benz AG and Chrysler Corporation, Jürgen Schrempp and Robert Eaton, announced that their two companies had decided ‘to get together in a merger of equals.’ The combined company would have $132 billion in annual revenues; it would be the fifth largest automaker in the world, employing 428,000 people – about one-half in Germany, one-third in North America, and the rest spread across 200 countries around the world. Although it was the largest industrial merger the world had seen to that date, the announcement took most observers by surprise. Negotiations had been conducted under strict secrecy, with only a very limited number of persons from each company involved. At the London press conference, both CEOs explained the rationale for the merger. In their opinion, both companies were too small on a global scale to prosper in the long-term. This handicap, they felt, could be overcome by joining forces; their product ranges and geographical reach made the two enterprises near perfect partners (refer to Figures 1 and 2). At the press conference, the CEOs also publicly announced as one of their guiding principles that this move would be ‘a merger of growth; there will be no layoffs.’ They also stressed their determination to increase shareholder value, to obtain $1.4 billion in savings during the first year of the merger, and to complete the integration process within three years. After the dust of this ‘big bang’ had settled, some of the details of the merger’s secretive preparation became known. The marriage had indeed had a most interesting courtship.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2277
    Keywords: Key words Rat liver transplantation ; Intrahepatic leukocytes ; Dendritic cells ; T lymphocytes ; Chimerism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Long-term graft acceptance and tolerance induction after allogeneic rat liver transplantation are well described. However, the underlying mechanisms remain unclear. In this study we investigated the cellular events within the liver graft during initial immunosuppression and long-term acceptance. Orthotopic liver transplantation was performed in the Dark Agouti (DA)-to-Lewis (LEW) and LEW-to-DA rat strain combination. In order to achieve long-term acceptance, LEW recipients of DA livers were treated with two different short-term therapies. Non-parenchymal cells (NPC) were isolated from liver allografts on days + 10 and + 100 after transplantation and donor-specific leukocytes were immunophenotyped by flow cytometry. Both the monotherapy and triple therapy prolonged graft survival (〉 100 days). Liver allografts from LEW donors into DA recipients were spontaneously accepted across a complete MHC mismatch without immunosuppression. Liver allograft rejection was induced by infiltrating alloreactive immunocompetent cells. But the intensities of cell infiltration in the early and late phases after transplantation did not correlate with eventual outcome. Donor-specific NPC decreased to 18–25 % on day + 10 in both therapeutic groups, but had rebounded to up to 40 % by day + 100. Recurrence of donor-specific cells was caused almost exclusively by rising T cell counts. The persistence of dendritic cells in the late phase after transplantation could be clearly demonstrated. Repopulation by donor-specific T lymphocytes was observed in long-term accepted liver grafts. This recurrence may be based on the differentiation of liver-derived progenitor cells. The persistent coexistence of donor and recipient cells within the liver allograft (intrahepatic chimerism) appears to be characteristic and may be important for long-term acceptance.
    Type of Medium: Electronic Resource
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