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  • 1
    Electronic Resource
    Electronic Resource
    CLINICAL ASPECTS OF PREGNANCIES ESTABLISHED WITH CLEAVING EMBRYOS GROWN IN VITRO (1980)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 87 (1980), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Details are given of four pregnancies established by fertilization in vitro and planting cleaving embryos into the mother. The pregnancies were monitored by hormone assays in early pregnancy and by ultrasound scans. Amniocentesis was used to assess the levels of alpha-fetoprotein and the karyotype of the fetuses at 15 weeks. Placental function tests and X-rays were used to monitor late pregnancy in one patient. Three of the pregnancies began uneventfully and the fetuses were normal in all respects. Two were delivered at or near term, the third being aborted spontaneously at 21 weeks while the parents were on holiday. The fourth pregnancy did not develop normally and a triploid fetus was aborted 12 weeks after the last menstrual period. The clinical difficulties inherent in selecting patients and preparing them for treatment are described. Some possible improvements in techniques are also described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1980.tb04611.x
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  • 2
    Electronic Resource
    Electronic Resource
    ESTABLISHING FULL-TERM HUMAN PREGNANCIES USING CLEAVING EMBRYOS GROWN IN VITRO (1980)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 87 (1980), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The establishment of human pregnancies by the use of fertilization in vitro and placing cleaving embryos into the uterus is described. Preovulatory oocytes were aspirated at laparoscopy from the ovaries of patients soon after the beginning of the mid-cycle surge of luteinizing hormone (LH) during the natural cycle. The LH surge was identified by assaying 3-hourly samples of urine, and measurements of oestrogens in 24-hour samples were used to assess follicular growth. The surge of LH was identified in 68 patients and it showed a diurnal rhythm. Preovulatory oocytes were aspirated from most of the patients. Fertilization and cleavage occurred in 34 instances, and 32 embryos were put into the mother via the cervical canal. Four patients became pregnant. There were indications that a diurnal rhythm played a role in establishing cleaving embryos, each of the four pregnancies occurring when the embryos were placed in late evening. Each of the pregnancies resulted from oocytes which were aspirated from their follicles 24 hours or longer after the LH surge began. Details are given of three abortive pregnancies in patients given gonadotrophins to stimulate the maturation of oocytes used for fertilization in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1980.tb04610.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    OBSERVATIONS ON PREOVULATORY HUMAN OVARIAN FOLLICLES AND THEIR ASPIRATES (1980)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 87 (1980), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: During laparoscopy for the collection of preovulatory oocytes the ovaries were inspected and the numbers of Graafian follicles were counted. Most patients had one large preovulatory follicle but three patients had two and might have had twin ovulations. The large follicle was in the left ovary in 9 patients and in the right ovary in 11. It could be aspirated easily in most patients, viscous follicular fluid, presumably rich in hyaluronic acid, appeared to accumulate in preovulatory follicles between 18 and 27 hours after the luteinizing hormone surge. The content of steroids in follicular fluids indicated that the largest follicle was preovulatory in most patients, the smaller follicles being non-ovulatory. Granulosa cells aspirated from the large preovulatory follicles were active on the Δ4 pathway and able to aromatise androgens to oestrogens, but did not undertake conversions on the Δ5 pathway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1980.tb04612.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    GYNAECOLOGICAL ENDOSCOPY—LAPAROSCOPY AND CULDOSCOPY (1965)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 72 (1965), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1965.tb00063.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    MEMORANDUM ON VAGINAL HYSTERECTOMY (1965)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 72 (1965), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1965.tb01502.x
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  • 6
    Electronic Resource
    Electronic Resource
    Human Blastocysts grown in Culture (1971)
    [s.l.] : Nature Publishing Group
    Nature 229 (1971), S. 132-133 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Six embryos were cultured. The pH of the medium was 7.3, the osmotic pressure 300 mOsmol/kg, and the gas phase consisted of 5 % oxygen, 5 % carbon dioxide and 90 % nitrogen. Two of the embryos developed to early morulae, one having more than twenty-three nuclei, and the other twenty-nine nuclei and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/229132a0
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Fertilization and Cleavage in vitro of Preovulator Human Oocytes (1970)
    [s.l.] : Nature Publishing Group
    Nature 227 (1970), S. 1307-1309 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Human oocytes have been taken from the mother before ovulation, fertilized in vitro and grown in vitro to the eight- or sixteen-celled stage in various ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2271307a0
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  • 8
    Electronic Resource
    Electronic Resource
    Did Fertilization Occur? (1969)
    [s.l.] : Nature Publishing Group
    Nature 221 (1969), S. 981-982 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR,-We consider the earlier stages of fertilization include attachment of spermatozoa to the zona pellucida, their movement through it and the presence of spermatozoa in the perivitelline space. Our data1 gave convincing evidence in many eggs of the accomplishment of these earlier stages, and this ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/221981c0
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  • 9
    Electronic Resource
    Electronic Resource
    Early Stages of Fertilization in vitro of Human Oocytes Matured in vitro (1969)
    [s.l.] : Nature Publishing Group
    Nature 221 (1969), S. 632-635 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Human oocytes have been matured and fertilized by spermatozoa in vitro. There may be certain clinical and scientific uses for human eggs fertilized by this ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/221632a0
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Factors influencing the success of in vitro fertilization for alleviating human infertility (1984)
    Springer
    Journal of assisted reproduction and genetics 1 (1984), S. 3-23 
    Details
    ISSN: 1573-7330
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The program for in vitro fertilization at Bourn Hall began in October 1980. Various types of infertility have been treated during this time using the natural menstrual cycle or stimulation of follicular growth with antiestrogens and gonadotrophins. Follicular growth and maturation are assayed by urinary estrogens and LH, monitored regularly during the later follicular stage. Many patients had an endogenous LH surge; others needed an injection of HCG to induce ovulation. All oocytes were recovered by laparoscopy. Wide variations occurred in the time interval between the start of the LH surge and oocyte recovery and between oocyte recovery and insemination. Embryos taken between ooc one- and the eight-cell stage were replaced into their mother, no standard procedure being adopted for all patients. The results of all treatments including patient's responses during the follicular and luteal phases, oocyte recovery, fertilization, cleavage, replacement, implantation, abortion, and birth and the effect of factors such as replacing two or more embryos, maternal age, and previous obstetric history are described in detail. The incidence of implantation after embryo replacement improved from 16.5% initially to 30% currently. More than 118 babies have been born, and many pregnancies are continuing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01129615
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