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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 90 (1986), S. 711-713 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Public Health 13 (1992), S. 415-430 
    ISSN: 0163-7525
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 25 (1985), S. 67-95 
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0819
    Keywords: Key words Ruapehu ; Tufa Trig Formation ; Holocene ; Tephra ; Hydrovolcanic ; Pyroclast morphology ; Crater Lake ; Marker beds
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  Tufa Trig Formation comprises a sequence of at least 19 andesitic tephras erupted from Mt. Ruapehu (Tongariro Volcanic Centre, New Zealand). Tephras of Tufa Trig Formation are the most recent eruptives from Ruapehu, dated between ca. 1850 years B.P. and the present. Members of the Formation show restricted dispersals, principally to the east of Mt. Ruapehu. Volumes calculated for the most widespread members are all less than 0.1 km3. Compared with other Mt. Ruapehu eruptives, Tufa Trig Formation tephras represent small eruptions that have contributed little tephra to the ring plain. They do, however, show a greater frequency of eruption with one event occurring on average every 100 years. Tufa Trig Formation members Tf3–Tf18 are black to dark grey, vitric, coarse-ash and lapilli-grade tephras which mantle the relief. They contain juvenile vitric particles which exhibit varying degrees of vesicularity, together with free crystals of pyroxene and feldspar, and few lithic fragments. Several morphological types of vitric pyroclasts are recognised in these tephras, the dominant type being of equant blocky morphology with fracture-bound surfaces (type-1 morphology). Field characteristics, tephra distributions, and the morphologies and textures of constituent pyroclasts suggest that these members (Tf3–Tf18) are the products of small-volume hydrovolcanic eruptions resulting from the interaction of fresh magma and meteoric water. We propose that a source of this water was an ancestral crater lake which formed within the late Holocene ca. 3000 years B.P. The morphological, compositional, and chemical (major-element) characteristics of three Tufa Trig Formation Tephras are compared with those of two new tephras erupted from Ruapehu Volcano during the October 1995 eruptions which comprise part of a newly defined member (Tf19) of Tufa Trig Formation. The comparisons support our interpretation that the majority of the Tufa Trig Formation tephras are primarily the products of hydrovolcanic eruptions. Other members of the Formation (Tf1 and Tf2) are coarse-grained scoriaceous tephras and are interpreted to be the products of strombolian events.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-2072
    Keywords: Ethanol-induced impairment ; Renin-angiotensin system ; Mineralocorticoid ; Prostaglandin synthetase inhibitor ; Furosemide ; High salt-low salt diet ; Spironolactone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Ethanol-induced motor impairment in rats was measured following a number of different dietary or drug treatments. A low sodium diet combined with injections of the diuretic furosemide, but not a low sodium diet alone, increased motor impairment while a high sodium diet decreased impairment. Blood ethanol measurements indicated that both effects were probably mediated by changes in blood ethanol levels. However, the synthetic mineralocorticoid, DOCA, and the nonsteroidal anti-inflammatory, indomethacin, both altered ethanol-induced motor impairment without concomitant changes in blood ethanol levels. The aldosterone antagonist, spironolactone, failed to produce any effect. Since all treatments can modulate activity in the renin-angiotension system, this system appears to play a role in altering some of the behavioral properties of ethanol.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 79 (1983), S. 318-321 
    ISSN: 1432-2072
    Keywords: Ethanol ; Active and passive avoidance ; Aversive control ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The ability of ethanol to motivate avoidance responding was used as a measure of the drug's aversive stimulus properties. In Experiment I, four groups of rats were infused with either ethanol (200, 400, 800 mg/kg IV) or saline if they failed to jump a high hurdle. The ethanol groups acquired the jumping response (active avoidance), while the saline group only showed a tendency not to jump. In Experiment II, the hypothesis was tested that the same infusions might be self-administered if the contingency were reversed so that responses produced rather than avoided the drug. Four groups of rats were given the same doses of ethanol or saline if they traversed a runway and entered a goal box. Initially, all animals made the response, however the drugtreated groups eventually showed a dose-dependent tendency to refrain from entering the goal box (passive avoidance). Thus ethanol can maintain behavioral control similar to that produced by commonly used aversive stimuli (e.g. foot shock) and can do so at lower doses than those found to be effective in previous reports of ethanol-mediated aversions. It is suggested that the mechanism by which ethanol comes to be a reinforcing agent must take into account the pervasive negative properties of the drug.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Nutrient cycling in agroecosystems 28 (1991), S. 281-293 
    ISSN: 1573-0867
    Keywords: MCP hydrolysis ; partially acidulated phosphate rock ; pH change ; phosphate diffusion ; solubility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract PAPR was made by partial acidulation of North Carolina phosphate rock with H3PO4. The PAPRs were incubated in bands in columns of two soils of contrasting P retention. The columns were sampled after freezing and sectioning with a cryomicrotome. The movement of P in soil incubated with33P-labelled PAPR was followed by autoradiography of polished epoxy impregnated sections of the freeze-dried soil column. PAPR solubility was also studied by a sequential dialysis process using distilled deionised water. The acid solution resulting from the dissolution of monocalcium phosphate (MCP) in PAPR moved into the surrounding soil, solubilizing soil minerals and creating a low-pH front with a high concentration of P. Depending on the soil, phosphorus moved 6–14 mm away from the fertilizer/soil interface by mass flow and diffusion in two days. The increase in 0.5 M NaOH extractable P above that of untreated soil showed a maximum at the same position as the pH minimum in the soil. In both soils, the total P movement from the fertilizer band after a two day period for 50% PAPR was comparable to that for 100% acidulation (≡triple superphosphate), indicating that acidulations above 50% did not necessarily increase the movement of soluble P from the fertilizer pellet. Variations in pH in the fertilizer-affected soil could be explained by the net balance of acidity resulting from incoming acid P solution and release of OH− during P sorption. The rock residue exhibited a transient loss in solubility which was reversed on subsequent dissolution, suggesting a possible surface alteration.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Nutrient cycling in agroecosystems 28 (1991), S. 295-304 
    ISSN: 1573-0867
    Keywords: Partially acidulated phosphate rock ; mineralogy ; phosphate fertilizers ; EDS analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract The fertilizer reaction products formed during the dissolution of PAPR fertilizer applied to two soils of contrasting P retention were studied using electron microscopy and energy dispersive x-ray spectrum (EDS) analysis combined with common mineralogical analysis procedures. Monocalcium phosphate (MCP) and phosphate rock (PR) residue were the main components of the PAPR fertilizer at the time of application. Dissolution of MCP in PAPR led to the formation of dicalcium phosphate dihydrate (DCPD) which was morphologically distinct from the soil matrix and easily analyzed by the microprobe. The amount of DCPD at the granule site was greater in the soil of low P retention than in the soil of high P retention, consistent with a greater transfer of fertilizer-P to the soil in latter case. The mean crystallite size of carbonate apatite in the fertilizer residue suggested a preferential dissolution of very fine crystallites at acidulations less than 50% during phosphoric acid acidulation. Electron microscopy showed dissolution of primary mineral grains (e.g. clinopyroxene) in soil adjacent to the fertilizer pellet during the dissolution of PAPR fertilizer. The precipitated products in the soil near the PAPR fertilizer pellet were complex compounds containing P, Ca, Al, Fe and Si. There was no evidence of pure phases such as variscite and strengite. These changes were analogous to those occurring in and around fully acidulated P fertilizers (TSP) in soil; however, in the case of PAPR, the reactive phosphate rock residue and DCPD at the site of application may provide a continuous source of P for plants over a long period.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 311 (1984), S. 47-48 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Accumulation of greater amounts of quartz in deep-sea sediments during glacial periods than during times of warmer climate has been recognized7'8 and been attributed to increased wind erosion from arid regions during those cold periods7"11. A marked change in global atmospheric circulation at the ...
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 26 (1984), S. 251-254 
    ISSN: 1432-1041
    Keywords: propranolol ; plasma protein binding ; age effects ; α1-acid glycoprotein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The extent of propranolol protein binding was determined in three different age groups of healthy drug-free caucasian males. Volunteers selected for study were 6–15 years old, 25–36 years old and 68–76 years old. Ten milliliters of blood were obtained via venipuncture and collected in glass tubes from the subjects after an overnight fast. Binding determinations were performed by equilibrium dialysis using radiolabelled propranolol. Serum albumin and α1-acid glycoprotein concentrations were determined in all subjects by radial immunodiffusion. The results obtained showed wide intersubject variability in the binding ratio of propranolol and serum concentrations of α1-acid glycoprotein. Mean albumin serum concentration was found to be significantly lower in the elderly group as compared to the adult and pediatric groups (p〈0.02). A positive correlation was found between the binding ratio of propranolol and the serum concentration of α1-acid glycoprotein in all the subjects (r=+0.66,p〈0.005). No significant correlation was found between the binding ratio of propranolol and the serum concentration of albumin (r=−0.03,p〈0.88). These data suggest that the extent of propranolol binding is influenced primarily by serum concentrations of α1-acid glycoprotein and not by differences in age.
    Type of Medium: Electronic Resource
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