ISSN:
1432-1912
Keywords:
NPY receptor
;
Muscarinic acetylcholine receptor
;
Ca2+
;
Inositol phosphates
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We have compared the mechanism of NPY-and carbachol-stimulated Ca2+ increases in SK-N-MC cells. NPY stimulated Ca2+ mobilization via a pertussis toxin-sensitive mechanism. Carbachol stimulated Ca2+ mobilization and influx via pertussis toxin-insensitive and -sensitive mechanisms, respectively. Carbachol but not NPY stimulated inositol phosphate accumulation by a pertussis toxin-insensitive mechanism. We conclude that carbachol promotes Ca2+ influx via a pertussis toxin-sensitive G protein and Ca2+ mobilization via a pertussis toxin-insensitive G-protein coupling to inositol phosphate generation; NPY stimulates Ca2+ mobilization via a pertussis toxin-sensitive G protein without apparent involvement of inositol phosphates.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00176612
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