ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
N-(4-Nitrophenyl)oxamic acid 1, N-(2-fluoro-4-nitrophenyl)oxamic acid 7, N-(4-nitrophenyl)-trifluoroacetamide 3, and N-(2-methoxy-4-nitrophenyl)trifluoroacetamide 9 are non-competitive inhibitors of Vibrio cholerae sialidase with Ki-values ranging from 2.66 to 5.18 · 10-4 M. These compounds, and the N-acetylneuraminic-acid analogues 11-13 do not inhibit the sialidase and trans-sialidase activities from Trypanosoma cruzi; nor does N-(4-nitrophenyl)oxamic acid (1) inhibit the corresponding enzyme activities from T. brucei.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19940770425
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