ISSN:
1573-8353
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Depending on the nature and amount of the base used, as well as the reaction time, the following compounds are formed in the reaction of 8-aminothiophyl-lines with glycerol epichlorohydrin in anhydrous propanol; 7-(2-hydroxy-3-chloro-1-propyl)-8-arylaminotheophylline, 1,3-bis(8-arylamino-7-theophyllinyl)-2-hydroxypropane, 7-(2,3-epoxy-1-propy1)-8-alkyl(aryl) aminothiophyllines or 9-alkyl(aryl)-7-hydroxy-1,3-dimethyl-6,7,8,9-tetrahydropyrimido [2,1-f]purine-2,4-(1H,3H)diones. The structures of the compounds were confirmed by alternative synthesis and by data from the IR spectra. The mass spectrum of one of the compounds is presented.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00503667
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