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  • 1
    Electronic Resource
    Electronic Resource
    Serum concentrations of organochlorine compounds and endometrial cancer risk (United States) (1998)
    Springer
    Cancer causes & control 9 (1998), S. 417-424 
    Details
    ISSN: 1573-7225
    Keywords: Endometrial cancer ; DDT ; PCB ; organochlorines ; United States ; women
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: Endogenous and exogenous estrogens are important in the development of endometrial cancer. Several organochlorine compounds, such as o,p′-DDT, have estrogenic properties. The objective of this case-control analysis was to examine serum concentrations of organochlorine compounds and risk of endometrial cancer. Methods: Analyses were based on a sample of 90 endometrial cancer cases and 90 individually matched community controls from a multicenter case-control study in five geographic regions of the United States. Information on potential confounders, including menstrual and reproductive factors, cigarette smoking, diet, and weight, was obtained by interview. Results: The adjusted relative risk of endometrial cancer in the highest quartile of exposure compared with women in the lowest quartile was 0.7 (95 percent confidence interval [CI] = 0.2-2.0) for p,p′-DDE, and 0.9 for total polychlorinated biphenyls (PCBs) (CI = 0.4-2.5). Conclusions: These findings do not support the hypothesis that organochlorine compounds are linked to the development of endometrial cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008823802393
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Menopausal estrogen and estrogen-progestin replacement therapy and risk of breast cancer (United States) (1994)
    Springer
    Cancer causes & control 5 (1994), S. 491-500 
    Details
    ISSN: 1573-7225
    Keywords: Breast cancer ; estrogens ; hormone replacement therapy ; progestins ; United States
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study examines the relationship between menopausal estrogen and estrogen-progestin replacement therapy and risk of breast cancer, focusing on whether associations differ according to whether the tumors arein situ or invasive. Data are from a prospective study conducted 1980–89 on 49,017 selected participants in the Breast Cancer Detection Demonstration Project, a five-year screening program conducted between 1973 and 1980 in the United States. Overall, the rate ratio for estrogen-only use compared with no-hormone use was 1.0, and that for the estrogen-progestin combination was 1.2 (95 percent confidence interval [CI]=1.0–1.6). However, the associations differed according to whether the tumors werein situ or invasive. The rate ratios ofin situ breast cancer associated with use of estrogens alone and the combination regimen were 1.4 (CI=1.0–2.0) and 2.3 (CI=1.3–3.9), respectively. Duration of estrogen-only use also was associated with risk ofin situ tumors, with users for 10 or more years at twice the risk of nonusers (P-value for trend test =0.02). Duration of use was not associated with risk of in vaisve cancer. Our results are consistent with the hypothesis that hormone replacement therapy is related to earlier-stage breast cancer; however, the possibility that the results reflect increased breast cancer surveillance among those taking hormones cannot be ruled out.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01831376
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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