ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
A new biodegradable adhesive(LYDEX) which is based on Schiff base formation haddeveloped. LYDEX is easy to control the setting time and degradation speed and it has no risk ofinfection. In the previous study, LYDEX showed high bonding strength and low cytotoxicity invitro[1]. In the present study, good bone repair was seen in rat bone defect models, especially inrapidly degrading type. On the other hand, slowly degrading type kept its shape longer withoutexcessive inflammation. In rabbit critical defect model with hydroxyapatite granules (HAs), morenewly formed bone was seen in rapidly degrading group and hydroxyapatite group, in 3weeks. In6weeks, more new bone was seen in slowly degrading type group, whereas, almost no new bonewas seen in deep area of the fibrin group, in 12weeks. Direct bonding between HAs and bone wasseen in HA group and LYDEX groups. These findings suggest that LYDEX with hydroxyapatitegranules can be a promising bone substitute
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.575.pdf
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