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  • 1
    Electronic Resource
    Electronic Resource
    Genetic counselling in psoriasis: empirical data on psoriasis among first-degree relatives of 3095 psoriatic probands (1997)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 137 (1997), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The risk of getting psoriasis dependent on the occurence of psoriasis in the family has been determined empirically. Altogether 3717 families with one or both parents who had psoriasis have been analysed with regard to the number of children with or without psoriasis. The lifetime risk of getting psoriasis if no parent, one parent or both parents have psoriasis is 0.04, 0.28 and 0.65, respectively. If there is already one affected child in the family, the corresponding risks are 0.24, 0.51 and 0.83, respectively. The risk of getting psoriasis before the age of 32 years is dependent on the age-of-onset of psoriasis in one affected parent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1997.19892070.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Age at onset and different types of psoriasis (1995)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 133 (1995), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary The age at onset of psoriasis has been analysed for 11,366 psoriasis patients. The age at onset for siblings of probands has been analysed for 805 probands having one affected sibling and for 1 79 probands having two affected siblings. The age at onset curve for all probands shows a dominating maximum at about puberty but also indications for two more maxima at about 30 and 50 years of age, respectively. A more relevant picture of the risk of getting psoriasis at different ages is obtained if the onset for old people having psoriasis is investigated. The three maxima come out more clearly in this case, and the puberty maximum is not so dominating. For the families with one proband and two affected siblings there is a statistically significant correlation (Plt;0·001) between the age at onset of the proband and of the siblings, and also between the siblings. The correlation coefficient is between 0·30 and 0·45. For the probands with one affected sibling, the ages at onset of the siblings mainly fall in the same range as those of the probands. These data indicate three groups of patients with respeel to age at onset. However, the overlap between the different groups is considerable. The data presented are compatible with three, possibly genetically different, variants of psoriasis vulgaris. By studying the occurrence of psoriasis among parents of the probands, the gene frequency can be estimated assuming a recessive mode of inheritance. It then turns out that the gene frequency of the group with the earliest age at onset has a gene frequency of about 0·25, the next earliest, 0·18, and the latest, 0·14.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1995.tb02753.x
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  • 3
    Electronic Resource
    Electronic Resource
    A population genetic study of psoriasis (1994)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 131 (1994), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We present epidemiological data for 5197 families with psoriasis. Errors in reporting have been analysed. Analysis of the data provides indications of random mating with respect to whether the partner has the skin disease or not. Data on psoriasis among parents, siblings and children are provided, and particular attention has been paid to the age at onset of psoriasis. Psoriasis was present in the parents of about 36% of the probands. In families in which one or both parents have psoriasis, the occurrence of the disease among the siblings does not provide any information which differentiates between a dominant and recessive mode of inheritance, but is compatible with both. In families in which neither parent had psoriasis, provided there was a proband with psoriasis, the probability of the siblings suffering from psoriasis was close to 0.25, indicating a recessive mode of inheritance. The distribution of psoriasis among the parents of all probands, and among the children of probands, was also compatible with this mode of inheritance. The prevalence of psoriasis in the elderly was estimated to be about 5%, and the gene frequency in the whole population 25%.These findings show that, with regard to first-degree relatives, the inheritance of psoriasis can fit an autosomal recessive model. The concept of a recessive mode of inheritance may be used as a basis for genetic counselling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1994.tb08454.x
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  • 4
    Electronic Resource
    Electronic Resource
    Oral psoralen photochemotherapy (PUVA) of hyperkeratotic dermatitis of the palms (1983)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 109 (1983), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Oral psoralen photochemotherapy (PUVA) was found to be effective in five patients with chronic hyperkeratotic dermatitis of the palms. Relapses may occur but they respond well to retreatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1983.tb07082.x
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  • 5
    Electronic Resource
    Electronic Resource
    Prevalence of hand eczema in an industrial city (1987)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 116 (1987), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The occurrence of hand eczema in an industrial city was studied. Questionnaires were sent to 20000 individuals aged 20–65 years, randomly selected from the population register of the city. After two reminders, a response rate of 83% was obtained. Analysis of the drop-outs did not indicate that the presence of hand eczema was an important selection factor for response to the questionnaire. Those subjects considering themselves to have had hand eczema within the previous 12 months were invited to a dermatological examination to verify the diagnosis and for further investigation. Seventy-one per cent accepted the invitation. Analysis of drop-outs showed that willingness to attend the dermatological examination was to some extent dependent on the severity of the hand eczema.It was found that almost 11% considered themselves to have had hand eczema at some time during the previous 12-month period; approximately two thirds were women. Five point four per cent had had hand eczema at a particular point in time (prevalence) and 2% had had continuous problems with hand eczema during the previous year.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1987.tb05895.x
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  • 6
    Electronic Resource
    Electronic Resource
    UV-B doses received during different outdoor activities and UV-B treatment of psoriasis (1982)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 106 (1982), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Measurements have been made of the biologically-effective environmental UV-B radiation received by people pursuing a variety of outdoor leisure activities. These UV-B doses have been compared with those received from artificial UV-B radiation by patients undergoing treatment for psoriasis. The results indicate that the therapeutic doses are not dissimilar to those received by active sunbathing for the same period during the summer months.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1982.tb00899.x
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  • 7
    Electronic Resource
    Electronic Resource
    Home solarium treatment of psoriasis (1979)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 101 (1979), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1979.tb15286.x
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  • 8
    Electronic Resource
    Electronic Resource
    Petite Mutants induced in Yeast by Dithranol (1,8,9-trihydroxyanthracene), an Important Therapeutic Agent against Psoriasis (1967)
    [s.l.] : Nature Publishing Group
    Nature 214 (1967), S. 415-415 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Some other compounds that form complexes with DNA, like acridine derivatives, 3,4-benzpyrene, and 1,2,5,6-dibenzanthracene, are mutagenic or carcinogenic3,4. It may therefore be suspected that dithranol also has a mutagenic effect. A very sensitive test for the mutagenic effect of acridine ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/214415a0
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  • 9
    Electronic Resource
    Electronic Resource
    Interaction between deoxyribonucleic acid and some anthracene and anthraquinone derivatives
    Amsterdam : Elsevier
    BBA Section Nucleic Acids And Protein Synthesis 123 (1966), S. 630-633 
    Details
    ISSN: 0005-2787
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2787(66)90235-8
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  • 10
    Electronic Resource
    Electronic Resource
    A low-angle X-ray diffraction study of bacterial flagella
    Amsterdam : Elsevier
    BBA - Specialised Section On Biophysical Subjects 88 (1964), S. 422-429 
    Details
    ISSN: 0926-6577
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0926-6577(64)90198-6
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