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  • 1
    Electronic Resource
    Electronic Resource
    Tryptophan depletion and aggressive responding in healthy males (1996)
    Springer
    Psychopharmacology 126 (1996), S. 97-103 
    Details
    ISSN: 1432-2072
    Keywords: Serotonin ; Tryptophan ; Aggression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to study the effect of decreasing plasma tryptophan levels on aggressive responding in a controlled laboratory setting, we administered two doses (25 g and 100 g) of a tryptophan-free amino acid mixture to ten healthy male subjects after 24 h of a low tryptophan diet. Subjects were screened for current or past psychiatric, or non-psychiatric medical illness. Aggressive responding on a free-operant laboratory measure of aggression (the Point Subtraction Aggression Paradigm) and plasma tryptophan levels were measured before and after drinking the amino acid mixture. There was a significant increase in aggressive responding 5 h after the 100 g mixture and a significant increase in aggressive responding 6 h after the 25 g mixture compared to a baseline day when no drink was administered. There was also a significant decrease in plasma tryptophan at 5 hours after ingestion compared to baseline for both doses of amino acid mixture. This study supports the hypothesis that tryptophan depletion increases aggressive responding in healthy males in a laboratory setting; probably by decreasing brain serotonin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02246343
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Thyroid hormone and norepinephrine: Effects on alpha-2, beta, and reuptake sites in cerebral cortex and heart (1988)
    Springer
    Journal of neural transmission 71 (1988), S. 195-205 
    Details
    ISSN: 1435-1463
    Keywords: Thyroid hormone ; methimazole ; noradrenergic receptors ; desipramine ; clonidine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thyroid hormone produces metabolic effects similar to those of stimulation of noradrenergic receptors. It has been reported, however, that norepinephrine turnover is reduced during thyrotoxicosis and that beta-noradrenergic receptor number is increased. Metabolic effects of thyroid hormone may therefore reduce noradrenergic activity. We examined effects of thyroid hormone administration or production of hypothyroidism with methimazole on receptors associated with regulation of noradrenergic function. Treatment with thyroid hormone increased beta-receptor binding, increased alpha-2 receptor binding, and decreased desipramine binding, opposite to effects of hypothyroidism produced by methimazole. Heart was more sensitive than brain to these effects. These data are consistent with reduced noradrenergic activity during hyperthyroidism, possibly mediated by an increase in autoreceptor function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01245713
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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