ISSN:
1569-8041
Keywords:
follicular lymphoma
;
high-dose therapy
;
purging
;
randomized trial
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Background:The CUP trial was initiated to analyze the value ofhigh-dose therapy and stem-cell transplantation and purging in patients withrelapsed chemosensitive follicular NHL. Patients and methods:After three cycles of chemotherapyresponsive patients were randomized to either three more cycles of the samechemotherapy (C), high-dose therapy followed by autologous unpurged (U) orpurged (P) stem-cell transplantation. Purging was performed using a cocktailof monoclonals. Pretransplant conditioning consisted of cyclophosphamide (60mg/kg × 2) and total body irradiation. Results:Of the 140 patients registered from 26 centers in Europe,89 fulfilled the criteria for randomization (C: 24, U: 33 and P: 32). Reasonsfor failure to randomize were: no response (28), persistent marrowinfiltration (4), patient refusal (7), other (7), no data (5). With thecurrent follow up (median 26 months from randomization) 16 (66%) in Care known to have progressed or relapsed, in contrast to 13 (39%) ofU and 12 (37%) of the P patients (P-value 0.002). Overallsurvival is premature with the current available data. Conclusions:Patients in U and P arms had higherprogression/relapse-free survival rate. There are some suggestions of someimprovement in overall survival rate.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008339921975
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