ISSN:
1600-0765
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The aim of this study was to evaluate the effect of spiramycin on subgingival microflora and periodontal tissues in 10 patients, divided into 2 groups of 5 patients each, with 14 sites studied in each group. The 28 sites were examined at baseline, immediately before drug or placebo intake and then 2 and 4 weeks later. The assessment included oral hygiene status, gingival conditions, bleeding on probing, crevicular fluid and morphotype count by darkfield microscopy. On a double blind basis, patients received, at random, placebo (control group) or spiramycin (test group) 3 g the first day and 2 g daily during a fortnight. In the test group, results at 2 wk examination showed a statistically significant increase (p〈0.05) in coccoid cells, and reduction of motile rods and spirochetes, as well as pocket depth decrease. Plaque Index, Gingival Index and Crevicular Fluid only changed at 4 wk examination. No changes were recorded for the control group. The above improvements were maintained up to 15 d following drug administration. The authors suggest that spiramycin could be used profitably as an adjunct to mechanical therapy in reducing the periodontopathic flora.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1600-0765.1987.tb01582.x
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