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  • 1
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 18 (1983), S. 0 
    ISSN: 1365-3083
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The genetic control of the granulomatous response to viable Mycobacterium lepraemurium (MLM) was studied in C3H and C57BL/6 inbred strains, BXH recombinant inbred strains, (C3H × C57BL) F1 hybrids, and backcross mice. The results indicate that an autosomal dominant gene, or linked complex of genes, has a marked influence on the footpad reaction to viable MLM. The distribution of responders and non-responders among 12 BXH recombinant inbred strains and linkage analysis in C3H × (C3H × C57BL)F1 backcross mice indicated that the response gene(s) are linked to the H-2 complex on chromosome 17. The same gene(s) also influence host restriction of MLM multiplication and thus appear to be the first H-2-linked gene(s) influencing resistance to a bacterial infection.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Mathematische Zeitschrift 186 (1984), S. 407-417 
    ISSN: 1432-1823
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Mathematische Zeitschrift 198 (1988), S. 331-337 
    ISSN: 1432-1823
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    Journal of mathematical biology 4 (1977), S. 1-20 
    ISSN: 1432-1416
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Summary An important role of myoglobin in red muscle is to facilitate the diffusion of oxygen for metabolism. We consider a model for muscle respiration in which the oxygen consumption is of a MichaelisMenten form. The resulting mathematical model is solved in two different ways with two different boundary conditions. The first uses the singular perturbation method of Murray (1974), while the second, which gives another justication of the simpler procedure, is a direct numerical computation of the full problem. The oxygen tension and saturation are often small. For realistic values of the Michaelis-Menten constant the oxygen tension, the saturation and the radius of the region in which the oxygen tension is negligibly small can be calculated using the constant consumption model of Murray (1974), with corrected boundary conditions (those for a Stefan problem), which in certain circumstances markedly affect the solution.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    International journal of colorectal disease 4 (1989), S. 197-199 
    ISSN: 1432-1262
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We have investigated excision biopsy of anal skin tags as an adjunct to rectal biopsy in the diagnosis of Crohn's disease. Twenty-six patients with proven Crohn's disease of the large and/or small bowel were studied. All had perianal skin tags removed under local anaesthesia as outpatients, when rectal biopsies were also obtained. Three sections from each skin tag and three from each rectal biopsy were examined for granulomas. The rectal biopsies were also examined for changes ‘suggestive’ of Crohn's disease. Anal skin tags from 26 patients without Crohn's disease acted as controls. Of the patients with Crohn's disease, granulomas were found in both anal skin tags and rectal biopsies in five patients, in anal skin tags only in four, and in rectal biopsies only in three. When present, granulomas were more plentiful in anal skin tags than in rectal biopsies, being seen in all 3 sections in 7 of 9 ‘positive’ tags (i. e.: in 31% of 78 sections), compared to only 1 of 8 ‘positive’ rectal biopsies (i. e.: in 13% of 78 sections). No granulomas were seen in control anal skin tags. The procedure provides a simple technique which is complementary to rectal biopsy, by which histological confirmation of Crohn's disease may be obtained.
    Materialart: Digitale Medien
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  • 6
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature 256 (1975), S. 644-646 
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] The autosomal prealbumin locus (Pre) determines the per-sence or absence of a minor serum protein band that migrates ahead of the albumin band on electrophoresis14. Density of the band is hormone dependent, and is greatest in sexually mature males. The Prea allele determines the presence of the ...
    Materialart: Digitale Medien
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  • 7
    Digitale Medien
    Digitale Medien
    Springer
    European spine journal 8 (1999), S. 34-39 
    ISSN: 1432-0932
    Schlagwort(e): Key words MRI ; Intervertebral ; disc ; Low back pain ; Sciatica ; Discography
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Annular tears are manifest on MRI as the high-intensity zone (HIZ) or as annular enhancement. Patients with annular tears may experience low back pain with radiation into the lower limb in the absence of nerve root compression. Inflammation of nerve roots from leak of degenerative nuclear material through full-thickness annular tears is a proposed mechanism for such leg pain. The aim of this study is to illustrate the appearance of extradural enhancement adjacent to annular tears in patients being investigated for low back pain with radiation into the lower limb(s). Sagittal T1- and T2-weighted spin echo and axial T1-weighted spin echo sequences were obtained in eight patients being investigated for low back and leg pain. In all patients, the T1-weighted sequences were repeated following intravenous gadopentetate dimeglumine (Gd-DTPA). Annular tears were identified at 12 sites in eight patients. Extradural inflammation appeared as a region of intermediate signal intensity replacing the fat between the posterior disc margin and the theca, which enhanced following Gd-DTPA. The inflammatory change was always associated with an annular tear, and in four cases directly involved the nerve root. Enhancement of the nerve root was seen in two cases. The findings may be relevant in the diagnosis of chemical radiculopathy secondary to inflammation at the site of an annular leak from a degenerating disc.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    Springer
    European spine journal 7 (1998), S. 36-39 
    ISSN: 1432-0932
    Schlagwort(e): Key words Discography ; Lumbar ; intervertebral disc ; Back pain ; Discitis ; MRI
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The study aimed to identify and characterise changes occurring in the vertebral end-plate on MRI following uncomplicated lumbar discography. MRI was performed immediately before and within 2 h after uncomplicated lumbar discography in 20 consecutive patients undergoing the study as a precursor to possible spinal fusion. Of these, seven patients underwent a further MRI study at a mean of 72 days after discography (range 19–183 days). The MRI scans were assessed for the presence of any changes in the end-plates prior to and following discography. End-plate changes were identified in eight patients (40%) prior to discography. No new changes in end-plate signal intensity (SI) were identified in either the immediate or delayed MRI studies. The study suggests that any changes occurring in the vertebral end-plate following discography should be considered due to infectious discitis. There is no support for the concept of chemical discitis, chemical irritation of bone or microfracture of subchondral trabeculae as a cause of pain at discography.
    Materialart: Digitale Medien
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  • 9
    Digitale Medien
    Digitale Medien
    Springer
    European spine journal 7 (1998), S. 358-362 
    ISSN: 1432-0932
    Schlagwort(e): Key words Low back pain ; Radiculopathy ; Discography ; Intervertebral disc
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract This study aimed to identify the morphological abnormalities of the intervertebral disc, as demonstrated by lumbar discography, that are associated with pain radiation to the hip, groin, buttock or lower limb. We carried out a retrospective review of 99 consecutive lumbar discogram reports. The association of disc degeneration, annular tears (partial or full thickness) and the level of disc injected was determined with respect to the presence and pattern of radiating pain. A total of 260 discs were injected, of which 179 were considered abnormal. Posterior annular tears were demonstrated in 84 discs, anterior annular tears in 15 discs and 45 discs had both anterior and posterior tears. A significant association was identified between isolated posterior tears and the production of concordant radiating pain (P = 0.0041). No difference was identified between partial thickness posterior tears and full thickness posterior tears associated with leak of contrast medium, with regard to radiating pain. Similarly, there was no significant association between disc level injected and the pattern of pain radiation. The results indicate that pain experienced in the buttock, hip, groin or lower limb can arise from the posterior annulus of the intervertebral disc without direct involvement of the nerve root.
    Materialart: Digitale Medien
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  • 10
    ISSN: 1432-0932
    Schlagwort(e): Key words Low back pain ; MRI ; Discography ; Vertebral end-plate
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The vertebral end-plate has been identified as a possible source of discogenic low back pain. MRI demonstrates end-plate (Modic) changes in 20–50% of patients with low back pain. The aim of this study was to investigate the association between Modic changes on MRI and discogenic back pain on lumbar discography. The MRI studies and discograms of 58 patients with a clinical diagnosis of discogenic back pain were reviewed and the presence of a Modic change was correlated with pain reproduction at 152 disc levels. Twenty-three discs with adjacent Modic changes were injected, 21 of which were associated with pain reproduction. However, pain was also reproduced at 69 levels where no Modic change was seen. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for a Modic change as a marker of a painful disc were 23.3%, 96.8%, 91.3% and 46.5% respectively. Modic changes, therefore, appear to be a relatively specific but insensitive sign of a painful lumbar disc in patients with discogenic low back pain.
    Materialart: Digitale Medien
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