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  • 1
    Electronic Resource
    Electronic Resource
    Expression of integrin adhesion molecules in endometrium and endometriosis (1994)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 101 (1994), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To compare the expression of cell adhesion molecules by endometrium and endometriosis.Design A comparative study of integrin expression, determined immunohistochemically, in eutopic and ectopic endometrium biopsied synchronously from patients with endometriosis diagnosed at laparoscopy or laparotomy.Setting University Departments of Obstetrics and Gynaecology, and Pathology, Southampton; Department of Obstetrics and Gynaecology, Newcastle upon Tyne.Samples Eighteen paired samples of endometria and endometriosis.Results A wide distribution of collagen-laminin receptor proteins was demonstrated. α1 integrin expression was limited to secretory endometrium. β3 expression was only demonstrated on proliferative endometrium.Conclusions Expressions of the integrin proteins differed between the various elements of the endometrium. Cyclical changes in integrin expression also were demonstrated. No difference in cell adhesion molecule expression was seen when comparing endometrial and endometriosis samples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1994.tb13187.x
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  • 2
    Electronic Resource
    Electronic Resource
    Endometriosis: still an enigma (1993)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 100 (1993), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1993.tb14225.x
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  • 3
    Electronic Resource
    Electronic Resource
    AUTHORS' REPLY (1995)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 102 (1995), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1995.tb09149.x
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  • 4
    Electronic Resource
    Electronic Resource
    Low levels of amniotic fluid placental alkaline phosphatase in Down's syndrome (1993)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 100 (1993), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To investigate amniotic fluid placental alkaline phosphatase (PLAP) levels in normal and trisomy 21 pregnancies.Design Cross sectional study.Setting A tertiary referral prenatal diagnostic service.Subjects Three hundred and eleven women with singleton pregnancies of normal karyotype between 10 and 23 weeks gestation and 31 women with pregnancies associated with trisomy 21 Down's syndrome.Outcome measures PLAP levels were measured by immunoradiometric assay in amniotic fluid obtained by amniocentesis.Results Amniotic fluid PLAP was detectable from 12 weeks gestation and the median value rose to a peak of 4.57 iu/1 at 18 weeks. Pregnancies associated with Down's syndrome had significantly lower levels with a median multiple of median (MoM) of 0.638, (U = 3374, P= 0.0016, 95%CI = 0.50, 0.89). For the 20 women with trisomy 21 pregnancies detected at 16 to 18 weeks, the median MoM was 0.482, (U = 3694, P= 0.0011, 95%CI = 0.37, 0.85).Conclusion These data demonstrates that PLAP levels are reduced in the amniotic fluid of women carrying a fetus with trisomy 21.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1993.tb14312.x
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  • 5
    Electronic Resource
    Electronic Resource
    Combining medical and surgical treatment for endometriosis: the best of both worlds? (1992)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 99 (1992), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1992.tb13531.x
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  • 6
    Electronic Resource
    Electronic Resource
    The combination of a depot gonadotrophin releasing hormone agonist and cyclical hormone replacement therapy for dysfunctional uterine bleeding (1991)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 98 (1991), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective— To observe if a combination of a depot GnRH agonist and cyclical hormone replacement therapy decreases menstrual b od loss.Design— open, observational study comparing the objective assessment of menstrual blood loss before, during and after 3 months treatment.Subjects— 20 women with a subjective complaint of heavy menstrual loss in whom no cause could be discovered.Interventions— Each woman received 3 months of depot goserelin (Zoladex) combined with cyclical hormone replacement therapy (Cyclo-Progynova, 1 mg). Menstrual loss and symptoms were assessed before, throughout and after the study.Main outcome measures— Changes in objective and subjective assessments of menstrual blood loss and the acceptability of the treatment.Results— The median pretreatment menstrual loss was 68 ml (range 23–397). Only 8 (40%) of the patients had a loss exceeding 80 ml per period. The median blood loss was 30 ml, 16 ml, and 17 ml in the three treatment cycles (P 〈 0.001 Wilcoxon rank sum for the third cycle). There was a significant decrease in the median length of menstruation (P 〈 0.001) and the number of towels or tampons (P 〈 0.01) used per period in the third treatment cycle. There was a significant decrease (P 〈 0.005) in the number of women complaining of dysmenorrhoea, premenstrual symptoms, flooding and the passage of clots. Seventeen patients experienced hot flushes. Eighteen of the 20 patients were completely satisfied with the treatment and would have been happy to continue with it for longer than 12 months.Conclusions— The combination of a depot gonadotrophin releasing hormone agonist and cyclical hormone replacement therapy is a successful and acceptable treatment of dysfunctional uterine bleeding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1991.tb15369.x
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  • 7
    Electronic Resource
    Electronic Resource
    Epidermal growth factor receptor expression in normal endometrium and endometriosis: an immunohistochemical study (1992)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 99 (1992), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To study epidermal growth factor (EGF) receptor expression in endometrium throughout the menstrual cycle and to compare EGF-receptor expression in endometrium from patients with endometriosis with receptor expression in synchronously sampled endometriosis and in endometrium from healthy women.Design An immunohistochemical study of receptor expression using murine monoclonal antibodies and timed endometrial and endometriotic biopsies.Subjects 25 healthy women and 27 patients with a diagnosis of endometriosis.Results Positive staining for EGF receptors was observed in 24 of 25 samples from normal women and in 26 of 27 endometrial samples from patients with endometriosis. In neither group was there any variation in the intensity of staining throughout the menstrual cycle and both glands and stroma were stained. EGF-receptor expression was observed in the glands of 15 out of 17 endometriotic lesions and in 12 of these biopsies positive staining was also present within endometriotic stroma.Conclusion This study shows no difference in the intensity of staining of EGF receptors in endometrium throughout the menstrual cycle or between the glands of normal endometrium and those of endometriosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1992.tb13756.x
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  • 8
    Electronic Resource
    Electronic Resource
    Suppression of gonadotrophin secretion does not reverse premature ovarian failure (1989)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 96 (1989), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. The effect of prolonged inhibition of gonadotrophin secretion was studied in 12 women with premature ovarian failure. All the patients had plasma concentrations of follicle-stimulating hormone (FSH) 〉20 i.u./l, and in six, primordial follicles had been seen on ovarian biopsy. Goserelin (Zoladex, ICI), a depot synthetic analogue of luteinizing hormone-releasing hormone (LHRH) was administered by three consecutive 4-weekly injections. Plasma concentrations of luteinizing hormone (LH) fell from 34 (SD ll) i.u./l to 2·4 (SD 1·9)i.u./l, and plasma concentrations of FSH fell from 106 (SD29) i.u./l to 4·5 (SD 2·6) i.u./l 4 weeks after the first injection. Plasma concentrations of gonadotrophins returned to pretreatment values in every patient within 9 weeks of the final injection of goserelin. Regular ultrasonography during the period following the final injection failed to demonstrate the development of ovarian follicles in any patient, and plasma concentrations of oestradiol remained below 100 pmol/l. This study has failed to show that suppression of gonadotrophin secretion reverses premature ovarian failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1989.tb01662.x
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  • 9
    Electronic Resource
    Electronic Resource
    Fetal nuchal translucency: ultrasound screening for fetal trisomy in the first trimester of pregnancy (1995)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 102 (1995), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1995.tb11446.x
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  • 10
    Electronic Resource
    Electronic Resource
    Influence of training on reliability of surgical knots (2001)
    Oxford, UK : Blackwell Science Ltd
    BJOG 108 (2001), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objectives To determine whether trainees in obstetrics and gynaecology tie adequate surgical knots and to assess whether formal training improves knot tying skills.Design A comparative study assessing surgical knots before and after tuition.Population Fourteen trainees in a single obstetrics and gynaecology department.Setting A basic surgical skills workshop based in a London teaching hospital.Methods Trainees tied surgical knots around a 120mm jig using 2/0 glycan polymer. Each trainee tied 11 knots before and after a two and a half hour teaching session. Knots were tested using a mechanical testing machine.Outcome measures Knot strength (N); proportion of knots that were ‘secure’ (defined as those that eventually failed on the testing device by breakage rather than slippage); proportion of knots that were ‘dangerous’ (defined as those with a tensile strength of 〈 5 N).Results After tuition, the median knot strength of the whole group was 5.7 N stronger than before instruction (95% CI 4.6–12.3 N). Prior to tuition 13.5% (20/148) knots tied had a tensile strength of 〈 5 N. This was compared with 3.4% (5/148) after tuition (OR = 0.2, 95% CI 0.1–0.6). Before instruction 55.4% (82/148) of the knots were secure compared with 66.9% (99/148) after tuition (OR = 1.6, 95% CI 1.0–2.7).Conclusion Knot tying workshops can improve the ability of trainees in obstetrics and gynaecology to tie reef knots.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.2001.00251.x
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