ISSN:
1365-3083
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
In this study, results are presented which are in agreement with predictions made on basis of the ‘three-Stage hypothesis’ on the development of benign monoclonal gammapathy (BMG). In a T-cell depletion model, C57BL/Ka nude mice were shown to develop single and multiple homogeneous immunoglobulins (H-Ig) during aging in the highest frequencies known so far. Ninety percent of the C57BL/Ka nude mice displayed one or more H-Ig at 12 months of age. In a T-cell supplementation model, infusion of corticosteroid resistant T cells into 9-month-old BALB/c nude mice resulted in a decrease in the Frequency of H-Ig from 43% at 9 months down to 20% at 15 months of age. In contrast, the frequency of H-Ig in the control group increased from 40% at 9 months up in 68% at 12 months. The results show that normally functioning T cells are essential for the generation of a normal, heterogeneous Ig spectrum; they further support the validity of the three-stage hypothesis with regard to the role of an impairment of the T immune system in the pathogenesis of BMG.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-3083.1988.tb01461.x
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