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  • 1
    Electronic Resource
    Electronic Resource
    Induction of Malignant Lymphomas by Urethane in Adult Mice bearing Syngeneic Thymus Grafts (1965)
    [s.l.] : Nature Publishing Group
    Nature 208 (1965), S. 398-398 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Previous work showed that urethane (ethyl carbamate) in adult mice was practically devoid of leukaemogenic activity6'7, although effective in inducing thymic changes8. On the other hand, administration of this chemical to new-born animals was found to provoke a significant number of malignant ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/208398a0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Lymphatic Neoplastic Transformation of Thymus in Mice with Myeloid Virus-induced Leukaemia (1965)
    [s.l.] : Nature Publishing Group
    Nature 208 (1965), S. 697-698 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] C51BL mice received subcutaneously, within 48 h after birth, 0-05 ml. of cell-free extract containing Graffi virus, prepared as previously reported1. They were observed for development of leukaemia and killed when moribund. Among the 61 leukaemic mice examined both histologic-ally and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/208697a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Influence of Urethane on Susceptibility to Leukæmia Induction by Graffi Virus in Adult Mice (1963)
    [s.l.] : Nature Publishing Group
    Nature 199 (1963), S. 292-293 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The enhancing effect of urethane on radiation leukaemogenesis was well demonstrated by Berenblum and Trainin4, who observed a remarkable increase in leukaemia in C57BL mice receiving repeated doses of urethane after total-body irradiation. Since no comparable results were obtained when the sequence ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/199292a0
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  • 4
    Electronic Resource
    Electronic Resource
    Immunohistochemical characterization of nurse cells in normal human thymus (1991)
    Springer
    Histochemistry and cell biology 96 (1991), S. 499-503 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Lymphoepithelial complexes known as thymic “nurse” cells (TNC) have been isolated and described in the thymus of several animal species including man. Most of the investigations on TNC have been carried out in enzymatically digested thymuses in which TNC were isolated by differential sedimentation. In the present study we demonstrate TNC in immunohistochemically stained sections of human thymus as ring-shaped cells completely enclosing thymocytes and localized not only in the cortex, but also at the corticomedullary junction where they have not been previously described. TNC expressed epithelial markers [low and high molecular weight keratins identified by 35βH11 and 34βE12 monoclonal antibodies, a cortical antigen shared with neuroectodermal neoplasms recognized by the GE2 monoclonal antibody, and tissue polypeptide antigen (TPA:B1)], class II histocompatibility antigens (HLA-DR), and thymosin α1. Double staining experiments with the nuclear proliferation-associated antigen Ki-67 and the cortical epithelium marker GE2 showed that most thymocytes enclosed in these cortical TNC were not proliferating. The antigens expressed by TNC indicate that not only cortical, but also medullary epithelial cells are part of the TNC system. The possible role of TNC in the education and maturation of thymocytes is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00267075
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  • 5
    Electronic Resource
    Electronic Resource
    Binding of sheep erythrocytes in chronic lymphocytic leukemias of B-cell origin (1982)
    Springer
    Journal of clinical immunology 2 (1982), S. 296-302 
    Details
    ISSN: 1573-2592
    Keywords: Chronic lymphocytic leukemia ; E receptors ; antisheep antibody activity ; surface immunoglobulins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two patients with B chronic lymphocytic leukemia having leukemic cells that bind sheep red blood cells by different mechanisms are described. In the first case, rosette formation was mediated by the anti-sheep erythrocyte activity of a monoclonal surface IgMk, related to Forssman antigen. In the second, E-rosette formation was found to be independent of both surface immunoglobulins and the classic E-rosette receptor since the leukemic cells were recognized neither by the OKT-11 monoclonal antibody nor by other markers specific for T-cell lineage. Evaluation of these rare cases emphasizes that detection of surface immunoglobulins and spontaneous rosetting are not sufficient for the characterization of leukemic clones and raises some doubts concerning the use of available surface markers in the characterization of lymphoproliferative disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00915070
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