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  • 1
    Electronic Resource
    Electronic Resource
    Differences in Release Mechanisms and Distributions for Sialyl Lea and Sialyl Lex Antigens in Colorectal Cancer (2000)
    Springer
    Annals of surgical oncology 7 (2000), S. 289-295 
    Details
    ISSN: 1534-4681
    Keywords: Sialyl Lea ; Sialyl Lex ; Drainage vein ; Colorectal cancer.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: To investigate colorectal cancer-related carbohydrate antigen release and distribution, we evaluated serum levels of sialyl Lea (CA19–9) and sialyl Lex antigen (SLX) in blood samples obtained from both a peripheral vein and a tumor’s draining vein. Methods: Blood samples were obtained during surgery from 126 patients. Based on these samples, patients were placed into a high-antigen group, with a concentration above a selected cutoff value, or into a low-antigen group, with a tumor marker concentration below that same value. The blood samples obtained from peripheral veins were designated by the “p” prefix, and samples from drainage veins were designated by the “d.” Results: Serum d-SLX levels were significantly higher than p-SLX levels (P, .0001), although there was no difference between those of d-CA19–9 and p-CA19–9. Only 1 (3.6%) of 28 patients in the high d-CA19–9 group had a low p-CA19–9. In contrast, 6 (33.3%) of 18 patients in the high d-SLX group had low p-SLX levels (P 5 .0103). Correlations between pathological variables and either p-CA19–9 levels or d-CA19–9 levels were similar. However, both distant metastasis and venous invasion did prove to be independent variables related to d-SLX levels, as shown by logistic regression analysis. Conclusions: SLX may drain predominantly via the draining veins of colorectal tumors into portal circulation, whereas CA19–9 may drain via another route.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s10434-000-0289-1
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  • 2
    Electronic Resource
    Electronic Resource
    Upper airway obstruction from a benign goiter (1992)
    Springer
    Surgery today 22 (1992), S. 88-90 
    Details
    ISSN: 1436-2813
    Keywords: upper airway obstruction ; benign goiter ; acute resperatory failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acute upper tracheal obstruction from a huge benign goiter developed in an 80-year-old woman. Computed tomography showed severe stenosis of the cervical trachea by extrinsic compression. A left hemithyroidectomy was performed and the tracheal lumen returned to normal size. However, the tracheal wall was malacic due to the prolonged compression by the goiter and a silastic T-tube insertion was necessary for a two month period. This type of tracheal obstruction is rare. The importance of evaluating the upper trachea in patients with prolonged benign goiter is stressed and the diagnosis as well as the management of this type of complication are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00326133
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  • 3
    Electronic Resource
    Electronic Resource
    Numerical aberrations of chromosomes 11 and 17 in colorectal adenocarcinomas (1996)
    Springer
    Surgery today 26 (1996), S. 869-874 
    Details
    ISSN: 1436-2813
    Keywords: numerical chromosome aberration ; fluorescence in situ hybridization ; interphase cytogenetics ; colorectal adenocarcinoma ; lymph node metastasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fluorescence in situ hybridization (FISH) is an easy and efficient means of measuring numerical chromosome aberrations in the interphase nuclei of solid tumors; however, the correlation between numerical chromosome aberrations and the clinical stage of solid tumors remains unknown. Thus, in the present study, we investigated the relationship between numerical chromosome aberrations and clinicopathologic features in colorectal adenocarcinomas. FISH was applied to surgically resected colorectal cancer samples from 45 patients to evaluate the numerical aberrations of chromosomes 11 and 17. The mean age of the patients was 65.1 years, and they comprised 13 women and 32 men. According to Dukes' classification, 5 patients were categorized as stage A, 21 as stage B, 10 as stage C, and 9 as stage D. Histologically, 18 of the samples were lymph node metastasis-positive. FISH revealed numerical aberrations of chromosome 11 in 27 out of the 45 patients (60%), and those with a lower chromosome 11 number had a significantly lower incidence of lymph node metastasis (P〈0.05). Chromosome 17 proved to have numerical abnormalities in 33 of the 45 patients (73%), and those with a higher chromosome 17 number had more DNA aneuploidy (P〈0.005). This is the first report to reveal the relationship between monosomy 11 and lymph node metastasis in colorectal adenocarcinomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311787
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  • 4
    Electronic Resource
    Electronic Resource
    Analysis of p53 gene deletions in colorectal cancers using fluorescence in situ hybridization (1997)
    Springer
    Surgery today 27 (1997), S. 999-1004 
    Details
    ISSN: 1436-2813
    Keywords: colorectal cancers ; fluorescence in situ hybridization ; p53 gene ; double primary cancers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To examine the relationship between the incidence of p53 gene deletion in each nucleus and the clinicopathological features in colorectal cancers, we performed a cytogenetic study using fluorescence in situ hybridization (FISH). FISH was performed on 5 adenomas and 38 colorectal cancers that had been resected surgically. The nucleus, in which the copy number of the p53 signal was lower than that of chromosome 17, was determined as a deletion of the p53 gene. The mean frequency of the deletion of p53 in adenomas and cancers were 7.8%±3.0% and 57.0%±19.0%, respectively. Numerical aberrations of chromosome 17 or a deletion of p53 were also detected in DNA diploidy. The mean frequency of the deletion of p53 in 32 cases with aneusomy of chromosome 17 (65.7%±14.5%) was significantly higher than that in cases of disomy (51.1%±19.3%,P 〈0.05). Even though this frequency was high in the early stage, it was not associated with any specific histopathological features. This frequency was also higher in double primary cancers (70.4%±16.7%) compared with single colorectal cancers (53.4%±18.1%), (P〈0.05). Using FISH, our results demonstrated that the clonal deletion of the p53 locus is an early genetic event of colorectal cancers and that a high incidence of p53 deletion may influence the occurrence of double primary cancers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02385778
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  • 5
    Electronic Resource
    Electronic Resource
    Endobronchial leiomyoma: Report of a case treated by bronchoplasty and a review of the literature (1995)
    Springer
    Surgery today 25 (1995), S. 1057-1060 
    Details
    ISSN: 1436-2813
    Keywords: endobronchial leiomyoma ; bronchoplasty ; benign lung tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Endobronchial leiomyoma is exteemely rare. Most endobronchial leiomyomas reported in the literature have been resected by either lobectomy or pneumonectomy. We herein report a case treated by sleeve bronchoplasty without pulmonary resection. A 42-year-old woman was admitted to our hospital complaining of hemoptysis. Bronchoscopy revealed a lobulated tumor arising from the medial wall of the right main stem bronchus. A sleeve resection of the right main bronchus including the tumor and end-to-end anastomosis was performed. The histological diagnosis of the resected specimen was leiomyoma with no evidence of malignancy. The importance of early diagnosis and appropriate surgical treatment to preserve pulmonary function are emphasized. Similar cases of an endobronchial type of pulmonary leiomyoma reported in the literature are also reviewed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311694
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  • 6
    Electronic Resource
    Electronic Resource
    Quantitative analysis of numerical chromosome aberrations in various morphological types of colorectal carcinomas (1996)
    Springer
    Journal of gastroenterology 31 (1996), S. 793-800 
    Details
    ISSN: 1435-5922
    Keywords: fluorescence in situ hybridization ; chromosome index ; paraffin sections ; flat type cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Quantitative analysis by fluorescence in situ hybridization (FISH) on thin paraffin-embedded tissue sections, using specific probes for chromosomes 11, 17, and 18 was employed in various morphological types of early and advanced colorectal cancer to clarify tumor cytogenetics. The chromosome index (CI) was calculated as a quantitative measure of the chromosome copy number. Compared with the CI of normal epithelium, the CI of chromosome 11 in villous components of adenomas or polypoid early cancers was decreased, while the CI in flat type or advanced colorectal cancers, conversely, was increased (P〈0.05). The CI of chromosome 17 in villous components of adenomas and all cancers was higher than that of normal epithelium (P〈0.05), but the differences were not significant. In protruding advanced cancers, the CI of chromosome 18 was significantly decreased (P〈0.01) compared to the CI of normal epithelium. There was no significant chromosomal heterogeneity between the superficial and the deepest layer in each cancer. In mucosa adjacent to sessile and flat type cancers, the CI of chromosome 17 was significantly higher than the CI in normal epithelium or adenomas (P〈0.05). These results suggest that numerical chromosome aberrations are associated with the histological type of adenoma and the morphological diversity of cancer in the colorectum, and that chromosome 17 abnormality occurs in mucosa adjacent to sessile and flat cancers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02358604
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  • 7
    Electronic Resource
    Electronic Resource
    Bronchoplastic procedures for lung cancer: Clinical study in 136 patients (1994)
    Springer
    World journal of surgery 18 (1994), S. 822-825 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Entre 1969 et 1991, 136 patients (199 hommes et 17 femmes) ont eu une bronchoplastie pour cancer du poumon. On y a associé une angioplastie chez 37 patients. L'âge moyen des patients était de 62 ans (extrêmes de 30 à 79). Quatre-vingt sept patients (70.0%) avait un cancer épidermoïde. La mortalité à 30 jours était de 5.1% (7 patients) et la morbidité, de 30.1% (41 patients). La complication la plus fréquente a été une fistule bronchopleurale chez 9 patients (6.6%), une sténose chez 8 (5.9%) et une atélectasie chez 8 patients. On a observé une récidive locale chez 9 (6.6%) patients. La survie globale à 5 ans chez les patients ayant eu une bronchoplastie était de 37.1%: 60.1% pour les patients du stade I (n=41), 31.7% pour les patients du stade II (n=17) et 29.7% pour les patients du stade IIIA (n=66). Nous concluons que la bronchoplastie est efficace chez le patient ayant un cancer du poumon.
    Abstract: Resumen En el período 1969–1991 hubo 136 pacientes (119 del sexo masculino y 17 del femenino) sometidos a procedimientos broncoplásticos por cáncer pulmonar. En 37 pacientes se practicó un procedimiento broncoplástico con angioplastia. Las edades oscilaron entre los 30 y los 79 años, con un promedio de 62. Histológicamente, el tumor fue carcinoma escamocelular en 97 pacientes (70.0%). La mortalidad a 30 días fue 5.1% (7 pacientes)
    Notes: Abstract Between 1969 and 1991 a total of 136 patients (119 men, 17 women) underwent bronchoplastic procedures for lung cancer. A bronchoplastic procedure with angioplasty was performed in 37 patients. Ages ranged from 30 to 79 years (mean 62 years). The histologic type of cancer was squamous cell carcinoma in 97 patients (70.0%). The 30-day mortality was 5.1% (7 patients), and morbidity was 30.1% (41 patients). The most common complications were bronchopleural fistula in nine (6.6%), stricture or stenosis in eight (5.9%) and atelectasis in eight patients. Local recurrence occurred in nine (6.6%) patients. The overall 5-year survival for patients undergoing bronchoplastic procedures was 37.1%: 60.1% for patients with stage I disease (n=41), 31.7% for stage II (n=17), and 29.7% for stage IIIA (n=66). We conclude that bronchoplastic procedures are effective therapy for selected patients with lung cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00299075
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  • 8
    Electronic Resource
    Electronic Resource
    The relationship between circulating sialyl Tn antigen and polypoid or nonpolypoid growth characteristics in colorectal cancer (2000)
    Springer
    Journal of cancer research and clinical oncology 126 (2000), S. 542-548 
    Details
    ISSN: 1432-1335
    Keywords: Key words Sialyl Lea ; Sialyl Lex ; Sialyl Tn ; Colorectal cancer ; Polypoid growth type ; Nonpolypoid growth
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recent studies delineated two different patterns of tumor growth in colorectal carcinoma characterized as polypoid and nonpolypoid (PG-type and NPG-type, respectively). We quantified serum sialyl Lewis (Le)a (CA19–9), sialyl Lex (SLX), sialyl Tn (STN), and carcinoembryonic antigen (CEA) in 269 colorectal cancer patients to establish whether their levels correlated with any biological or clinical differences between PG-type and NPG-type cancer. Patients were divided into high and low antigen groups (higher or lower than a selected diagnostic-based cut-off value) and compared. Statistical testing was by univariate and multivariate (logistic regression) analyses. Forty-seven (17.5%) patients with PG-type and 222 (82.5%) with NPG-type cancer were studied. In contrast to NPG-type, the characteristics of the PG-type cancers included a low rate of lymph node metastasis and a high serum STN level. In contrast to a low STN level, a high STN level was independently related to the presence of distant metastasis in patients with PG-type cancer, and also to the presence of distant metastasis and large-sized tumor in patients with NPG-type cancer. These data suggest that differences in STN levels in the serum of patients with PG-type or NPG-type colorectal carcinomas may be at least partly responsible for different tumor progression behavior.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004320000129
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  • 9
    Electronic Resource
    Electronic Resource
    Expression of blood group antigens A, B and H in carcinoma tissue correlates with a poor prognosis for colorectal cancer patients (2000)
    Springer
    Journal of cancer research and clinical oncology 126 (2000), S. 375-382 
    Details
    ISSN: 1432-1335
    Keywords: Key words Blood group antigen ; ABH isoantigens ; Colorectal carcinoma ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The deletion of blood group ABH isoantigens on tumor tissues has been reported to be an adverse prognostic marker for patients with various solid tumors. In the present study, we evaluated the prognostic value of altered expression of ABH isoantigens in colorectal carcinomas. Using monoclonal antibodies, the expression of A, B, and H antigens was assessed by immunohistochemistry on paraffin-embedded carcinoma samples from 82 patients who had undergone surgery for colorectal cancer. ABH isoantigens were found to be deleted in 36 carcinomas (43.9%) and expressed in 46 (56.1%). Univariate and multivariate analysis using a logistic regression model revealed that N factor (lymph node metastasis) and blood group type were independently related to the expression of ABH isoantigens. In contrast to previous reports on other cancers, patients whose colorectal carcinomas express ABH isoantigens had a poorer prognosis than those whose carcinomas showed deletion of ABH isoantigens (P = 0.0008). The expression of ABH isoantigens was an independent prognostic variable, in addition to T (depth of tumor invasion), N, and M (distant metastasis) factors, as shown by means of Cox regression analysis. In conclusion, the expression of ABH isoantigens in carcinoma tissue is an important poor prognostic factor in patients with colorectal cancer. This variable needs to be considered in the design of future trials of therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00008485
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  • 10
    Electronic Resource
    Electronic Resource
    Gallbladder cancer a comparative study among clinicopathologic features, AgNORs, and DNA content analysis (1996)
    Springer
    Digestive diseases and sciences 41 (1996), S. 840-847 
    Details
    ISSN: 1573-2568
    Keywords: gallbladder cancer ; AgNORs ; DNA ploidy ; prognosis ; malignant behavior
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A comparative study among clinicopathologic features, silver-stained nucleolar organizer region associated proteins (AgNORs), and DNA content analysis in 76 patients with gallbladder cancer was performed. The AgNOR count, AgNOR area, and the ratio of AgNOR area to nuclear area were significantly higher in patients with a low grade of histological differentiation and deep invasion into the gallbladder wall. Moreover, these parameters were higher in cases with lymph node involvement and distant metastases. DNA ploidy pattern and clinicopathologic features showed no statistical significance. Our results demonstrate that AgNOR parameters are useful indicators to evaluate the malignant behavior of gallbladder cancer. Furthermore, the AgNOR count together with the depth of the neoplastic invasion and lymph node metastases proved to be independent prognostic factors for survival in patients with gallbladder cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02091520
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