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  • 1
    Electronic Resource
    Electronic Resource
    Lymph Node Metastasis-Related Carbohydrate Epitopes of Gastric Cancer with Submucosal Invasion (2000)
    Springer
    Surgery today 30 (2000), S. 1073-1082 
    Details
    ISSN: 1436-2813
    Keywords: Key words Early gastric cancer ; Lymph node metastasis ; Carbohydrate ; Lectin ; Sialyl Tn antigen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study was conducted to examine the lymph node metastasis-related carbohydrate epitopes of cancer cells in primary lesions of gastric cancer with submucosal invasion (sm gastric cancer). A total of 118 formalin-fixed and paraffin-embedded surgical specimens were studied. Carbohydrate epitopes were de-tected histochemically using 17 kinds of biotin-labeled lectins and three kinds of monoclonal antibodies (mAbs) against Thomsen-Friedenreich antigen (HB-T1), Tn (HB-Tn1), and sialyl Tn antigens (HB-STn1). The node-positive group showed significantly lower reactivities with Ricinus communis I (RCA-I), Lotus tetragonolobus (Lotus), Triticum vulgaris (WGA), and Concanavalia ensiformis (ConA), and higher reac-tivities with HB-STn1. When sm gastric cancer was classified into differentiated and undifferentiated types, lower reactivities with RCA-I and ConA were observed in the differentiated type cancers, whereas lower re-activities with Lotus, WGA, and higher reactivity with HB-STn1 were observed in the undifferentiated type cancers. Nodal status was able to be predicted with high precision by a combination of these carbohydrates and histological subtypes. Since neuraminidase treatment rarely changed the reactivity of cancer cells with these lectins, we conclude that the loss of certain kinds of carbohydrates that are restricted by histological subtypes is related to lymph node metastasis in sm gastric cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005950070004
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  • 2
    Electronic Resource
    Electronic Resource
    Wheat germ agglutinin binding is a useful prognostic indicator in stomach cancer (1999)
    Springer
    International journal of clinical oncology 4 (1999), S. 96-100 
    Details
    ISSN: 1437-7772
    Keywords: Key words Wheat germ agglutinin ; Stomach cancer ; Lectin histochemistry ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. Recent studies suggest that lectin binding activity is correlated with the metastasis and prognosis of several human carcinomas. Wheat germ agglutinin (WGA) is a lectin that recognizes mainly N-acetyl-glucosamin (GalNAc) and acetyl-neuramic acid. However, little is known about WGA expression in gastric carcinoma. The purpose of this investigation was to clarify the significance of WGA expression in human gastric carcinoma. Methods. WGA binding was examined immunohistochemically in 353 specimens of primary gastric carcinomas from patients surgically treated at the First Department of Surgery, Fukushima Medical School, between 1980 and 1990. We studied the relationship between WGA expression and various clinicopathologic features and long-term survival. Results. Overall, 145/353 of the tumors (41%) were stained for WGA. WGA expression correlated with mean patient age, lymph node metastasis, venous invasion, and liver metastasis. Patients with tumors that were nonimmunoreactive for WGA had significantly lower 5-year survival rates than those with immunostained tumors (P 〈 0.05). WGA expression emerged as an independent prognostic factor on Cox's multivariate analysis. Conclusion. WGA binding is a useful prognostic indicator. Careful follow-up and intensive postoperative therapy are required for patients with gastric carcinomas that are nonimmunoreactive for WGA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101470050034
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  • 3
    Electronic Resource
    Electronic Resource
    Soybean agglutinin binding as a useful prognostic indicator in stomach cancer (1997)
    Springer
    Surgery today 27 (1997), S. 293-297 
    Details
    ISSN: 1436-2813
    Keywords: lectin histochemistry ; soybean agglutinin ; stomach cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Soybean agglutinin (SBA)-binding carbohydrate expression was studied immunohistochemically in 353 primary gastric carcinomas. The overall rate of positive SBA staining was 23% (81/353), and positive SBA staining was significantly correlated with tumor size, macroscopic tumor type, depth of invasion, lymph node metastasis, and venous invasion (P 〈 0.05). Moreover, patients with tumors that were immunoreactive for SBA demonstrated significantly higher survival (P 〈 0.01). From these findings we conclude that careful follow-up and intense postoperative therapy are required for patients with gastric cancers that lack immunoreactivity for SBA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00941800
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Sialyl-Tn antigen as a useful predictor of poor prognosis in patients with advanced stomach cancer (1998)
    Springer
    Surgery today 28 (1998), S. 682-686 
    Details
    ISSN: 1436-2813
    Keywords: sialyl-Tn antigen ; stomach cancer ; immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sialyl-Tn antigen (STn) expression was studied immunohistochemically in 211 primary advanced gastric carcinomas. The overall rate of positive STn staining was 17% (35/211), and positive STn staining was found not to be correlated with tumor size, depth of invasion, lymph node metastasis, liver metastasis, or peritoneal metastasis. However, patients with tumors that were immunoreactive for STn demonstrated significantly lower survival (P〈0.05). Multivariate analysis revealed that STn staining was an independent prognostic factor. From these findings we conclude that careful followup and intense postoperative therapy are required for patients with advanced gastric cancer who have positive immunoreactivity for STn.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02484612
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Sialyl-Tn Antigen as a Useful Predictor of Poor Prognosis in Patients with Advanced Stomach Cancer (1998)
    Springer
    Surgery today 28 (1998), S. 682-686 
    Details
    ISSN: 1436-2813
    Keywords: Key Words: sialyl-Tn antigen ; stomach cancer ; immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: P 〈 0.05). Multivariate analysis revealed that STn staining was an independent prognostic factor. From these findings we conclude that careful followup and intense postoperative therapy are required for patients with advanced gastric cancer who have positive immunoreactivity for STn.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005950050209
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    Paper (German National Licenses)
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