ISSN:
1619-7089
Keywords:
Iodine 123 metaiodobenzylguanidine
;
Myocardial scintigraphy
;
Hypertrophic cardiomyopathy
;
Sympathetic nervous system
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Whole-body distribution of iodine 123 metaiodobenzylguanidine (123I-mIBG) was evaluated in 27 patients with hypertrophic cardiomyopathy (HCM). At 1 and 4 h after injection, anterior and posterior whole body images were obtained with a dual-headed, camera computer system. Patients were classified into three groups based on the septal wall thickness as determined by echocardiography: group 1 consisted of 7 patients with ≤ 15 mm septal thickness, group 2 included 12 patients with 16–19 mm septal thickness, and group 3 included 6 patients with ≽ 20 mm septal thickness. Although the myocardial mIBG uptakes at 1 h were similar among these groups (1.84% ± 0.19%, 1.95% ± 0.38%, 1.98% ± 0.57%, respectively; NS), mIBG washout from the heart in group 3 was faster than in groups 1 and 2 (31.5% ± 13.0% vs. 15.8% ± 11.0% (group 1,P 〈 0.05), 17.6% ± 7.3% (group 2,P 〈 0.01)). There was a significant positive correlation between mIBG washout from the heart and septal thickness, with correlation coefficientr=0.52 (P 〈 0.01). The liver, lung, parotid gland, spleen and skeletal muscle showed similar mIBG uptake and washout among the three groups. We conclude from these data that mIBG washout from the heart in HCM was faster in patients with severe hypertrophy than in patients with mild to moderate hypertrophy, and hence it may be a useful parameter for evaluating the severity of altered adrenergic innervation and activities.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00812368
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