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  • 1
    Electronic Resource
    Electronic Resource
    Inhibitory effects of suramin on androgen-dependent and-independent growth of neonatal mouse seminal vesicles in vitro (1995)
    Springer
    Urological research 23 (1995), S. 127-133 
    Details
    ISSN: 1434-0879
    Keywords: Seminal vesicle ; Suramin ; Androgen ; Insulin ; Organ culture ; Epithelial growth
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of suramin on the growth of seminal vesicles (SVs) of neonatal mice were investigated in vitro. SVs from 0-day-old male mice were cultured in serum-free chemically defined medium supplemented with 5α-dihydrotestosterone (DHT, 10-8 M) and insulin (10 μg/ml), alone and in combination. Prior to culture. SVs from 0-day-old mice had no epithelial branches. SVs cultured in medium with DHT formed numerous epithelial branches, while epithelial branching did not occur in SVs cultured without DHT. The addition of suramin (0.2 mM) to medium containing DHT inhibited the formation of epithelial branches almost completely. Removal of suramin from the medium on days 2, 4, and 6 of culture initiated the formation of epithelial branches. Suramin (0.2 mM) reversibly decreased 3H-thymidine-labeling indices (3H-LI) of both epithelium and mesenchyme of SVs cultured in medium with DHT plus insulin or DHT alone during 8 days of culture. Suramin also decreased 3H-LI of both epithelium and mesenchyme of SVs cultured in medium with insulin alone. The present study indicates that suramin reversibly inhibits not only androgen-dependent but also androgen-independent growth and ductal branching morphogenesis of neonatal mouse SVs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307943
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Growth factors as mediators of androgen action during the development of the male urogenital tract (1995)
    Springer
    World journal of urology 13 (1995), S. 264-276 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Studies on the developing prostate and SV suggest that androgens act via mesenchymal AR to elicit synthesis and secretion of various autocrine and paracrine factors that regulate epithelial and stromal growth and differentiation. Clearly, the global regulation of epithelial growth and ductal branching morphogenesis is a complex multifactorial process involving the interplay of many diffusible factors (both positive and negative regulators), extracellular matrix molecules, cell-surface receptors for growth factors, receptors for extracellular matrix molecules, and matrix-degrading enzymes. Future progress will certainly be dependent upon the utilization of appropriate, biologically relevant models to examine the respective roles of various growth factors in the growth and development of androgen target organs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00185969
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Evaluation of Biochemical Markers of Bone Metabolism in Patients with Secondary Hyperparathyroidism (1999)
    Springer
    International urology and nephrology 31 (1999), S. 737-741 
    Details
    ISSN: 1573-2584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied the biochemical markers of bone metabolism and bone mineral density (BMD) in 43 male haemodialysis patients. We measured serum levels of carboxyterminal parathyroid hormone (PTH-c), carboxyterminal propeptide of human type I procollagen, calcitonin, intact osteocalcin, cross-linked carboxyterminal telopeptide of human type I collagen, and alkaline phosphatase. We divided all patients into 2 groups (group A and B), those with serum PTH-c levels of 7.5 ng/ml or higher, and those with levels lower than 7.5 ng/ml, respectively. In group A, the levels of markers for bone formation and for bone resorption were notably elevated, while BMD was not significantly decreased. The level of serum markers for bone metabolism appears to be more sensitive than BMD for the clinical assessment of secondary hyperparathyroidism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007185227485
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    Paper (German National Licenses)
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