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  • 1
    Electronic Resource
    Electronic Resource
    A Novel Model of Fibroblast-Mediated Cartilage Destruction (2005)
    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Scandinavian journal of immunology 61 (2005), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In rheumatoid arthritis (RA), fibroblasts have been shown to be crucial for disease progression as well as joint destruction. In the model of human/murine SCID arthritis, synovial explants as well as fibroblasts from human rheumatoid synovial membrane induce destructive arthritis in immunodeficient mice. Hereby, the underlying cartilage destruction is accomplished by murine fibroblasts. Therefore, murine destructive fibroblasts represent a promising tool to investigate destruction of articular cartilage and bone. In this context, a novel destructive murine fibroblast line (LS48) was examined for morphological, ultrastructural, immunological and functional cellular parameters. These cells were injected into knees of SCID mice. Subsequently, the animals were monitored for joint swelling and serological parameters of arthritis by radiological methods. Finally, cartilage destruction was assessed morphologically. Cultured LS48 cells exhibit characteristic features that resemble those of activated synovial fibroblasts in human RA. Expression levels of inducible nitric oxide synthase, interleukin-6, tumour necrosis factor-α and matrix metalloproteinases were comparable to those detected in invasive human fibroblasts. The instillation of 5 × 105 LS48 cells into the knee joints of SCID mice initiated a rapid progressive process, that caused cartilage destruction within 10 days, and morphological examinations revealed that articular cartilage was infiltrated by the fibroblasts injected previously. In summary, the intra-articular application of LS48 cells represents a rapid and highly reproducible model to investigate the initiation and progression of cartilage destruction in connection with RA therapy and represents an easy-to-handle animal model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0300-9475.2005.01536.x
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  • 2
    Electronic Resource
    Electronic Resource
    Cytoplasmic c-erbB2 and survival in Dukes’ B colorectal carcinoma (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 27 (1995), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1995.tb00032.x
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  • 3
    Electronic Resource
    Electronic Resource
    Behandlungskonzept von Adenomen der Papilla Vateri (2000)
    Springer
    Der Chirurg 71 (2000), S. 196-201 
    Details
    ISSN: 1433-0385
    Keywords: Keywords: Tumors of papilla of Vater – Diagnosis – Ampullectomy. ; Schlüsselwörter: Tumoren der Papilla Vateri – Diagnose – Ampullektomie.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Einleitung: Die häufigsten benignen Tumoren der Papilla Vateri sind mit ca. 80 % Adenome. Sie gelten als präcanceröse Läsionen mit einer Entartungsfrequenz von bis zu 30 %. Methoden: Wir behandelten im Zeitraum von 1.1.1997–28.2.1999 11 Patienten mit einem Adenom der Papilla Vateri. Bei 10 Patienten erfolgte eine Ampullektomie, ein Patient war funktionell inoperabel. Ergebnisse: Es war keine Operationsletalität zu beobachten. Bei 2 Patienten fand sich im Resektat ein pT1-Carcinom; bei einem der 2 Patienten, der ein high risk Carcinom hatte, wurde eine Nachresektion nach Kausch-Whipple durchgeführt. Neun der 10 operierten Patienten leben bei einer medianen Nachbeobachtungszeit von 12 Monaten ohne Rezidiv. Ein Patient verstarb ohne Rezidiv an einem Glioblastom. Schlußfolgerungen: Die Ampullektomie ist das Verfahren der Wahl für benigne Tumoren der Papilla Vateri. Bei low risk pT1-Carcinomen (G1/G2, L0) und R0-Resektion ist bei Hochrisikopatienten die lokale Resektion vertretbar. Bei high risk Tumoren (G3 und/oder L1) muß eine Kausch-Whipple Operation durchgeführt werden.
    Notes: Abstract. Introduction: The most common benign ampullary tumors are adenomas (80 %). They are considered as premalignant lesions with a transformation rate to carcinoma of up to 30 %. Methods: From 1 January 1997 to 28 February 1999 we treated 11 patients with adenoma of the ampulla of Vater. An ampullectomy was performed in 10 cases. One poor-risk patient could not be operated on. Results: No operative mortality occurred. In two patients a pT1 adenocarcinoma was diagnosed postoperatively. One of the two patients with a high-risk carcinoma underwent a second operation, a Whipple pancreatoduodenectomy. Nine of 10 patients had no recurrence with a median follow-up of 12 months. Conclusion: One patient died of glioblastoma. We would therefore recommend ampullectomy as the first-line treatment for benign tumors of the ampulla of Vater. In low-risk pT1 carcinoma (G1/G2, L0) and R0 resection, local excision is acceptable. In high-risk pT1 carcinoma (G3 and/or L1) Whipple pancreatoduodenectomy is mandatory.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001040050033
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  • 4
    Electronic Resource
    Electronic Resource
    Das Cronkhite-Canada-Syndrom Epidemiologie, Symptomatik, Morphologie und Therapie anhand eines Fallberichts und der Literatur (1997)
    Springer
    Der Chirurg 68 (1997), S. 710-714 
    Details
    ISSN: 1433-0385
    Keywords: Key words: Cronkhite-Canada syndrome ; Nonfamilial polyposis ; Juvenile polyposis ; p53 ; c-erbB2. ; Schlüsselwörter: Cronkhite-Canada-Syndrom ; nicht familiäre Polyposis ; juvenile Polyposis ; p53 ; c-erbB2.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Cronkhite und Canada hatten 1955 erstmals über die „nicht familiäre Polyposis“ berichtet. Charakteristisch sind juvenile, intestinale Polypen kombiniert mit ektodermalen Veränderungen. Die Ätiologie ist nach wie vor ungeklärt. Wegen der hohen Assoziation des Cronkhite-Canada-Syndroms (CCS) mit einem intestinalen Carcinom (16,5 %) muß eine maligne Transformation oder gar genetische Prädisposition in Betracht gezogen werden. Anhand einer Patientin mit CCS, die 2 Jahre nach initialer Diagnosestellung ein Coloncarcinom entwickelte, und der Literatur werden Epidemiologie, Symptomatik, Morphologie und Therapie diskutiert.
    Notes: Summary. Juvenile polyposis was first described by Cronkhite and Canada in 1955. This disease is characterized by juvenile intestinal polyps and ectodermal abnormalities. The etiology of Cronkhite-Canada syndrome (CCS), however, is still not well understood. Interestingly, among patients with CCS a significant correlation (16.5 %) with intestinal carcinomas has been observed. Thus, malignant transformation and/or genetic predisposition may be involved in the initiation of the disease. In the following, epidemiology, symptoms, morphology and therapy of CCS are discussed. Our examinations are based on studies reported in the literature and on a case report of a female patient who developed a colon carcinoma 2 years after initial diagnosis of CCS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001040050258
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  • 5
    Electronic Resource
    Electronic Resource
    Wertigkeit cytologischer Untersuchungen beim Staging solider Tumoren (1997)
    Springer
    Der Chirurg 68 (1997), S. 90-93 
    Details
    ISSN: 1433-0385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001040050157
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  • 6
    Electronic Resource
    Electronic Resource
    Anatomie und Pathologie des Gallengangskarzinom (1999)
    Springer
    Der Onkologe 5 (1999), S. 482-489 
    Details
    ISSN: 1433-0415
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Maligne Tumoren der Gallengänge sind insgesamt relativ selten. Bei diesen Tumoren überwiegen die epithelialen Neubildungen (Karzinome), mesenchymale Tumoren sind noch weitaus seltener. Karzinome der extra- und intrahepatischen Gallenwege entstehen durch maligne Transformation des Epithels der extrahepatischen Gallengänge sowie der großen und mittleren intrahepatischen Gangabschnitte. Dabei können die Karzinome intrahepatisch, als intrahepatische Gallengangskarzinome oder Cholangiokarzinome (CC), gelegen sein, aber auch die Ductus hepatici dexter/ sinister, Ductus hepaticus communis oder den extra- bzw. intraduodenalen Anteil des D. choledochus (extrahepatische Gallengangskarzinome) betreffen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007610050389
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of hepatocyte growth factor on the expression of E- and P-cadherin in gastric carcinoma cell lines (1994)
    Springer
    Virchows Archiv 425 (1994), S. 139-144 
    Details
    ISSN: 1432-2307
    Keywords: Hepatocyte growth factor ; Gastric cancer ; Adhesion molecules ; Cancer-stromal interactions ; c-met
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hepatocyte growth factor (HGF), identical to scatter factor, (SF) is a secretory glycoprotein from fibroblasts which dissociates and increases the motility of various types of epithelial cells. After treatment of three gastric carcinoma cell lines (MKN-28, MKN-45 and TMK-1) with HGF (10 ng/ml), TMK-1 cells lost their tight cell to cell contact and showed marked scattering, while the two other cell lines remained unaffected. To learn about the underlying mechanism of the HGF induced scattering, we examined the expression of adhesion molecules and growth factor/receptor systems at the mRNA and protein level. The observed scattering of treated TMK-1 cells was associated with a reduction in the expression of E- and P-cadherin protein. The respective mRNA levels remained unchanged after HGF/SF treatment. In the two other cell lines, which showed no scattering, there were no changes in the expression of E-and P-cadherin. All other growth factors and their receptors examined (TGF-α, EGFR, c-met and c-erbB2) remained constant and were not affected by HGF treatment. The results suggest that HGF/SF may regulate cell adhesion in gastric carcinomas via E-and P-cadherin expression at the protein level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00230350
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