ISSN:
1437-9813
Keywords:
Parenteral hyperalimentation
;
Insulin
;
Adrenergic alpha-receptor blockers
;
adrenergic beta-receptor blockers
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Hyperglycemia and relative hypoinsulinemia are characteristic in the post-traumatic period. The altered insulin kinetics in this phase are dependent on many factors, which include stimulation of adrenoreceptors of pancreatic beta-cells and increased urinary clearance of insulin. Using the young rabbit as an experimental model, two series of experiments were designed. In study 1 (effect of trauma on serum insulin/glucose [I/G] ratio and urinary loss of insulin) two groups of animals (control and trauma) on parenteral nutrition were studied during 4 days. In study 2, in an acute 3-h period the effects of alpha- and beta-adrenoceptor blockers on insulin secretion were investigated. The animals were divided into four groups: control, trauma, trauma + phentolamine, and trauma + propranolol. In study 1 it was demonstrated that after trauma there was a decrease in I/G ratio and an increase in urinary loss of insulin, but no alteration in absolute levels of serum insulin. In study 2 we could demonstrate that treatment with adrenoceptor blockers did not prevent the lowering effect of trauma on I/G ratio. It is suggested that the diabetes-like state of the post-injury period is a complex phenomenon that is dependent on other important factors, as well as catecholamine inhibition of insulin secretion.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00182520
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