ISSN:
1573-8221
Keywords:
hypoxia
;
Diamox
;
external respiration
;
respiratory center
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract In experiments on cats, inactivation of carbonic anhydrase by acetazolamide (Diamox) prevented the development of hypocapnia and associated disturbances of the firing pattern of respiratory neurons in acute hypoxia. However, comparison of the electrophysiological data, the indices of external respiration and the acid—base balance, and pO2 and pCO2 of arterial blood showed that, while preventing the development of pathological respiration of Cheyne—Stokes type during hypoxia, inactivation of carbonic anhydrase by Diamox causes dissociation of thoracic and abdominal respiration and dyspnea. Changes in metabolic processes and disturbance of electrolyte balance at the cellular level also contribute to the development of dyspnea.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00801053
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