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A double-blind clinical trial with a lotion containing 5% benzoyl peroxide and 2% miconazole in patients with acne vulgaris (1989)

MESQUITA-GUIMARÃES, J. ; RAMOS, S. ; TAVARES, M. R. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Clinical and experimental dermatology 14 (1989), S. 0

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ISSN: 1365-2230

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: The therapeutic effieaey of a lotion containing 5% benzoyl peroxide and 2% miconazole was compared with 5% benzoyl peroxide alone, in a double-blind, randomized, parallel study. Thirty patients with comedonal or inflammatory acne vulgaris were enrolled. The medications were applied once daily during the first week, and then twice daily for the rest of the trial (45 days). In patients with comedonal acne there was no difference in the effect of the two therapies. In patients with inflammatory acne the percentage reduction of the number of lesions on Day 30 was significantly higher in the benzoyl peroxide plus miconazole group (66%) compared to benzoyl peroxide alone (37%). At Day 45 there was a trend favouring the combined therapy but the difference was not signifieant. There were no significant differences i n the adverse reactions reported by the two groups of patients (erythema, itching or moderate exfoliation).

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-2230.1989.tb02584.x

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The mass spectrometric behaviour of benzohydroxaraic and benzothiohydroxamic acids under electron impact (1987)

Florěncio, M. H. ; Heerma, W. ; Santos, M. A. ; [et al.]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 22 (1987), S. 506-512

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ISSN: 0030-493X

Keywords: Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Primary fragmentation reactions in benzohydroxamic and benzothiohydroxamic acids have been studied and compared with those in benzamides and benzothioamides. Mass-analysed ion kinetic energy spectra, collisional activation spectra and spectral data from labelled compounds were used to elucidate fragment ion structures and reaction mechanisms. The mass spectra are shown to be dependent on ion source temperature. Losses of O and H2O are proved to be thermal in origin. The formation of an S… HO bond, which is analogous to an intramolecular hydrogen bond in solution chemistry, directs many fragmentation pathways. This seems to be the major factor determining the differences between the mass spectra of benzothiohydroxamic acids and those of the corresponding carbonyl compounds.

Additional Material: 2 Ill.