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  • 1
    Digitale Medien
    Digitale Medien
    Longitudinal changes in TCRB variable gene expression and markers of gingival inflammation in experimental gingivitis (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of clinical periodontology 25 (1998), S. 0 
    Details
    ISSN: 1600-051X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract. The aim of this study was to gain information of the cellular and molecular events which occur during the development of experimental gingivitis and to determine whether such changes occur in the presence or absence of alveolar bone resorption. Clinical, radiographic, biochemical and immunological variables were monitored in a 3-week, single-centre, experimental gingivitis study of 10 healthy volunteers. Following screening and professional prophylaxis to achieve visibly healthy gingival status, subjects abstained from all oral hygiene practises in one maxillary (test) quadrant for a period of 21 days. At days 0 and 21, in test and (contralateral) control quadrants, % bleeding on controlled pressure probing (% BOP) was calculated, and radiographic alveolar bone status was assessed using bilateral standardised vertical bite-wing radiographs and digital subtraction radiography (DSR) analysis. In test quadrants, gingival crevicular fluid (GCF) was sampled from 4 sites per subject with Periopaper strips, and prostaglandin E2 (PGE2) levels measured using an enzyme immunoassay (EIA) kit. At days 0, 7 and 21, one interdental papilla was surgically excised from the test quadrant, and the expression of T cell receptor B variable (TCRBV) genes was investigated using a reverse transcription-polymerase chain reaction (RT-PCR) procedure. At days 0, 7 and 21, peripheral blood lymphocytes (PBL) were isolated and additionally investigated for TCRBV gene expression. Following 21 days of plaque accumulation in test quadrants, a statistically significant increase in % BOP scores confirmed the presence of gingival inflammation (p〈0.001). DSR analysis revealed that there were no significant alveolar bone changes in either the test or control quadrants between days 0 and 21 (P 〉 0.05). EIA analysis of GCF samples identified a significant decrease in mean GCF PGE2 concentrations from day 0 to day 21 (P〈0.05). RT-PCR analysis indicated that genes from all 3 TCRBV families studied (TCRBV-2, -6, -8) were expressed in the PBL samples at all time points and in healthy gingival tissues at day 0. A restriction in the expression pattern of TCRBV genes similar to those which have previously been reported in chronic periodontitis was noted at gingivitis sites. It is possible that such an event may identify susceptibility to periodontal disease independently of other positive predictive markers such as GCF-PGE2.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-051X.1998.tb02369.x
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  • 2
    Digitale Medien
    Digitale Medien
    PRIMARY REFRACTORY ANAEMIA AND PREGNANCY (1968)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 75 (1968), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1968.tb01621.x
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  • 3
    Digitale Medien
    Digitale Medien
    Demonstration and Possible Significance of Uricase in Human Pathogenic Fungi (1962)
    [s.l.] : Nature Publishing Group
    Nature 194 (1962), S. 403-404 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Uric acid (Merck) was washed three times with warm distilled water and used for preparing a semifluid medium containing 10 gm. glucose, 5 gm. sodium chloride, 0-5 gm. magnesium sulphate, 1-0 gm. uric acid, 25 mgm. calcium chloride, 10 mgm. ferric chloride, 50 (JLgm. biotin, and 1-0 gm. washed agar ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/194403a0
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  • 4
    Digitale Medien
    Digitale Medien
    Prevalence of gingival overgrowth in transplant patients immunosuppressed with tacrolimus (2004)
    Oxford, UK : Munksgaard International Publishers
    Journal of clinical periodontology 31 (2004), S. 0 
    Details
    ISSN: 1600-051X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Aims: The study aims to determine the prevalence and severity of gingival overgrowth in a group of adult organ transplant recipients immunosuppressed with tacrolimus in comparison with ciclosporin, and to examine various risk factors for the development of gingival overgrowth.Methods: Forty patients taking tacrolimus were compared with 197 ciclosporin patients. Demographic, pharmacological and periodontal data were recorded for all patients. Comparison between the groups was made using independent sample t-tests, χ2 statistic or Mann–Whitney test. The effects of risk variables on overgrowth severity were examined using forward and backward stepwise regression analysis.Results: Those taking tacrolimus had a significantly lower mean gingival overgrowth score (14.1%) compared with ciclosporin (22.4%). Fifteen percent of the tacrolimus group had clinically significant gingival overgrowth compared with 30% in the ciclosporin group (p=0.053).Conclusions: The prevalence and severity of gingival overgrowth is less in adult transplant patients taking tacrolimus compared with ciclosporin. Concomitant use of calcium channel blockers and previous medication with ciclosporin are significant risk factors for the presence and severity of gingival overgrowth. Patients who have alteration of their immunosuppressant from ciclosporin to tacrolimus may persist in demonstrating gingival overgrowth attributable to their ongoing therapy with calcium channel blockers.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.0303-6979.2004.00459.x
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  • 5
    Digitale Medien
    Digitale Medien
    Plasma TGF-β1 as a risk factor for gingival overgrowth (2004)
    Oxford, UK : Munksgaard International Publishers
    Journal of clinical periodontology 31 (2004), S. 0 
    Details
    ISSN: 1600-051X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background and Aims: Induction of the pro-fibrotic growth factor TGF-β1 has been suggested as a possible mechanism through which immunosuppressant drugs may induce gingival overgrowth. This study aims to investigate plasma levels of TGF-β1 and relate them to the development and severity of gingival overgrowth in immunosuppressed transplant patients.Materials and Methods: One hundred and thirty-two ciclosporin-treated and 13 tacrolimus-treated transplant patients and 24 drug-free control subjects underwent a full periodontal examination including a determination of the presence and severity of gingival overgrowth.Results: Plasma TGF-β1 concentrations were determined by ELISA, and were found to be significantly elevated in samples from the transplant patients (mean=29.1 ng/ml) as compared with controls (mean=6.1 ng/ml, p〈0.0001). There was no significant difference between the levels of plasma TGF-β1 in the ciclosporin- and tacrolimus-treated patient groups.Conclusions: Furthermore, concomitant treatment with calcium channel blockers did not influence the levels of plasma TGF-β1 in the patients group. The relationship between gingival overgrowth, independent periodontal variables and TGF-β1 plasma concentrations was examined using univariate and multivariate regression analyses; low TGF-β1 plasma concentrations were found to be a risk factor for gingival overgrowth in immunosuppressed patients concomitantly receiving a calcium channel blocker.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-051X.2004.00572.x
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  • 6
    Digitale Medien
    Digitale Medien
    In vitro studies of lymphocyte apoptosis induced by the periodontal pathogen Porphyromonas gingivalis (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 34 (1999), S. 0 
    Details
    ISSN: 1600-0765
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Apoptosis has a physiological role in lymphocyte development and function serving to remove self-reactive T-cells in the thymus as well as activated peripheral T-cells when they are no longer required in the immune response. Evidence from the study of several pathogenic bacteria indicate that induction of premature cell death by apoptosis may be an important pathogenic mechanism promoting infection, inflammation and concomitant disease. In this paper we demonstrate that cultures of the periodontal pathogen Porphyromonas gingivalis (P. gingivalis) promote lymphocyte apoptosis in peripheral blood mononuclear cells (PBMC). We have used assays designed to investigate the different molecular and cellular changes associated with apoptosis. Thus flow cytometry revealed that whole cultures of P. gingivalis promoted cell shrinkage in the lymphocyte fraction of PBMC and analysis of hypodiploidy confirmed that the cellular changes were associated with nuclear changes characteristic of apoptosis. We also found that apoptosis was promoted in PBMC exposed to both whole P. gingivalis cultures and culture supernatant but not washed bacterial cells; this indicates that molecule(s) secreted into the medium were responsible for this activity and not a factor intrinsic to the bacterial cell. Furthermore heat treatment has no effect on the ability of P. gingivalis cultures to induce lymphocyte apoptosis. In summary, a soluble heat stable component of the supernatant from P. gingivalis cultures promotes lymphocyte apoptosis. These data establish the principle that bacteria-induced apoptosis may be an important feature of the pathogenesis of periodontal disease.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0765.1999.tb02225.x
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  • 7
    Digitale Medien
    Digitale Medien
    An ultrastructural study of sympathetic ganglion satellite cells in the rat 1. Normal and x-ray irradiated satellite cells (1973)
    Springer
    Journal of neural transmission 34 (1973), S. 215-234 
    Details
    ISSN: 1435-1463
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The ultrastructure of normal and irradiated satellite cells of the rat superior cervical ganglia was studied. Each neuron is closely and completely invested by satellite cell cytoplasm. The satellite cell cytoplasm usually contains a number of mitochondria, granular endoplasmic reticulum, Golgi apparatus, lysosome-like bodies, filaments, microtubules, lipid droplets, centriole and cilia. The satellite cell also encloses presynaptic nerve endings, and other nerve fibers. X-ray irradiation produces several changes in the satellite cells. These include: (a) increased nuclear density, (b) marked local widening of the perinuclear space, (c) dilation of granular endoplasmic reticulum and loss of attached ribosomes, (d) swelling of mitochondria with disorganization of mitochondrial cristae and loss of matrix, (e) increase in the number of vacuoles, and (f) increase in the number, size and contents of lysosome-like bodies.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01367511
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  • 8
    Digitale Medien
    Digitale Medien
    Dexhowardia tetraspora: A new hyphomycete with possible basidiomycete affinity (1970)
    Springer
    Mycopathologia 40 (1970), S. 305-308 
    Details
    ISSN: 1573-0832
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Dexhowardia tetraspora gen. et sp. nov. war als ein Kontaminant in einer Kultur die alsSporotrichum aureum erhalten worden ist, isoliert. Sie bringt Konidiophoren hervor, die denen ähnlich sind, wie man sie in der Konidialform vonFomitopsis annosus undF. insularis selten beobachtet. Da sie blasenförmige Konidiophoren völlig missen läßt, kann sie mitOedocephalum glomerulosum nicht als congenerisch betrachtet werden. Status perfectus ist unbekannt.
    Notizen: Abstract Dexhowardia tetraspora gen. et sp. nov. was isolated as a contaminant in a culture received asSporotrichum aureum. It produces conidiophores which resemble those infrequently observed in conidial states ofFomitopsis annosus andF. insularis. Because it entirely lacks ampullate conidiophores, it cannot be considered congeneric withOedocephalum glomerulosum. A perfect state is unknown.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02051783
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  • 9
    Digitale Medien
    Digitale Medien
    A comparison of some Ceratocystis species with sporothrix schenckii (1970)
    Springer
    Mycopathologia 42 (1970), S. 233-240 
    Details
    ISSN: 1573-0832
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Der sympodulosporogene Zustand vonC. minor, C. montia, C. multiannulata, C. narcissi, C. nigrocarpa, C. perparvispora undC. pilifera wurde mit typischen und atypischen Stämmen vonS. schenckii betreffs kultureller, morphologischer, serologischer Charakteristik und auf Virulenz für Mäuse untersucht. Mit einer möglichen Ausnahme waren alle Charakteristiken unter denCeratocystis-Arten dieselben oder sie wechselten wie diejenigen unter den Stämmen vonS. schenckii. Keine Stämme derCeratocystis hydrolysierten Stärke, während die Stämme vonS. schenckii getan haben. Alle die Arten und Stämme zeigten Kreuzreaktionen serologisch und in der Arthus-reaktion und zeigten dieselben groß-pathologischen Veränderungen nach intraperitonealen Injektionen mit Magenmuzin in der Maus. Außer etlicher Abwechslungen in Größe und Gestalt der Sympodulosporen und der hefe-ähnlichen Keimung, die in Gewebeausstrichen und in Kulturen bei 37°C beobachtet worden sind, waren dieCeratocystis-Arten nicht wesentlich unterschiedlich von typischen Stämmen vonS. schenckii.
    Notizen: Abstract Sympodulosporogenous states ofC. minor, C. montia, C. multiannulata, C. narcissi, C. nigrocarpa, C. perparvispora andC. pilifera were compared with typical and atypical strains ofS. schenckii from the aspects of some culture, morphological, serological characteristics, and mouse virulence. With a possible exception, all the former characteristics demonstrated among theCeratocystis species were either the same as, or varied in the same way as those observed amongS. schenckii strains. None of the former hydrolyzed starch, although all of the latter did. All species and strains cross reacted serologically in agglutination and Arthus-rype reactions, and produced similar gross pathological signs when injected with gastric mucin intraperitoneally into mice. Except for some variations in sizes and shapes of sympodulospores and of yeast-like budding forms observed in tissue smears and in cultures incubated at 37°C, theCeratocystis species were not significantly different from typical strains ofS. schenckii.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02051951
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  • 10
    Digitale Medien
    Digitale Medien
    Smooth muscle in the hepatic artery, portal vein and hepatic vein within the liver of the raccoon and guinea pig (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 262-265 
    Details
    ISSN: 1420-9071
    Schlagwort(e): Hepatic artery ; portal vein ; hepatic vein ; liver
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The amount and arrangement of smooth muscle in the intrahepatic vessels suggests that the guinea pig would be a good animal model for studying mechanisms controlling intrahepatic portal vein blood flow, while the raccoon would be good for studying hepatic vein mechanisms of control.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02002627
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