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  • 1
    ISSN: 1573-2622
    Keywords: c-wave ; electrooculogram ; electroretinogram ; incomplete congenital stationary night blindness ; visual evoked potential
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Three cases of congenital stationary night blindness are reported. In all patients a negative electroretinogram was recorded by single bright flash stimulation and changed to positive on sequential reduction of the stimulus intensities. Oscillatory potentials were recognized. Biphasic dark adaptation curves and moderate elevation of the relative logarithmic final threshold of dark adaptation were also found. Values of critical flicker fusion frequency were reduced to a mild or moderate extent. VEP latency was prolonged beyond the normal range in two cases. In all three the electroretinogram c-wave was extinguished despite a normal electrooculogram light-dark ratio. It is hypothesized that in congenital stationary night blindness some disorder may exist in the apical membrane of the retinal pigment epithelium but not in the basal membrane in view of dissociation between the c-wave response and the light rise in the electrooculogram.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-2622
    Keywords: Acetazolamide response ; electro-oculographic light rise ; human ; hyperosmolarity response ; retinal pigment epithelium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In an attempt to simplify the recording technique in electrophysiologic evaluation of the retinal pigment epithelium, we combined the electro-oculographic light rise, hyperosmolarity and acetazolamide responses in a single recording session. Recordings were performed in six normal subjects and in seven patients with diabetic retinopathy or retinitis pigmentosa. In the patients with background diabetic retinopathy, the hyperosmolarity responses were slightly reduced, while the acetazolamide response and the light rise was normal. In the patients with proliferative diabetic retinopathy, the hyperosmolarity response and light rise were remarkably reduced, while the acetazolamide response was normal. In the patients with retinitis pigmentosa, the hyperosmolarity response and light rise were decreased, while the acetazolamide response was normal. Despite a small study population, we concluded that the clinical results from our combined recording protocol were essentially the same as those reported for each response separately. Because this recording technique simplifies electrophysiologic evaluation of the retinal pigment epithelium, it may help clarify the mechanisms or localization of retinochoroidal and pigment epithelial diseases.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-2622
    Keywords: Adult T-cell leukemia ; Conjunctiva ; Leukemic cell infiltration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 77-year-old Japanese woman who had suffered from skin eruptions since 1986 was admitted in January, 1990. A diagnosis of adult T-cell leukemia/lymphoma (ATL) was made on the basis of clinical and laboratory data. On admission, erythematous lesions were present in both eyelids. Yellowish-white elevated lesions were found along the limbal conjunctiva, and extended segmentally into the cornea of both eyes. Microscopically, leukemic infiltration into the subepithelial layer of the conjunctiva was observed. Ophthalmic manifestations in ATL have not been well described, because of a little attention paid to them.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-2622
    Keywords: c-wave ; slow PIII ; peak time ; amplitude ; stimulus duration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Changes in peak time and amplitude of the direct current registered c-wave of the electroretinogram of the albino rabbit were investigated with various stimuli of duration ranging from 0.25 to 10 sec. The stimulus intensity was 500 lux at the surface of the cornea. Slow PIII was isolated by administrations of sodium iodate and sodium aspartate. The peak time of the c-wave was longer than that of the slow PIII in the range of stimulus duration less than 3.5 sec, but peak times were almost the same in the range above 3.5 sec. The amplitude of the c-wave at peak was larger than the corresponding amplitude of the slow PIII in the range less than 1 sec, but the slow PIII became larger than the c-wave at more than 1 sec. For stimuli less than 4 sec, the smaller the stimulus duration, the smaller was the negative slow PIII which affected the height of the c-wave. We conclude that in order to minimize the influence of the slow PIII on the c-wave, the duration of stimuli with intensity of 500 lux for recording the c-wave of the rabbit should be less than 4 sec.
    Type of Medium: Electronic Resource
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