ISSN:
1437-7780
Keywords:
pazufloxacin
;
suction blister fluid
;
pharmacokinetics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We investigated the pharmacokinetics of pazufloxacin (PZFX) in the fluid of suction blisters induced in the skin of 6 healthy male volunteers after a 200 mg oral dose of PZFX. The time to reach the maximum concentration (t max) of PZFX in plasma was 0.7 hours, and the maximum concentration (C max) was 2.95 μg/mL. The half-life of the elimination phase (t 1/2) in plasma was 1.75 hours, and the area under the concentration-time curve (AUC) was 6.70 μg·h/mL. Thet max,C max,t 1/2 and AUC values in the suction blister fluid were 2.0 hours, 1.52 μg/mL, 1.95 hours and 6.28 μg·h/mL, respectively. The ratio of the AUC of PZFX in blister fluid to the AUC in plasma was almost 1.0. Thus, excellent penetration of PZFX into suction blister fluid was observed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02355129
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