Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Journal of neurochemistry
21 (1973), S. 0
ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
—(1) The properties of a preparation of functional intact rat brain mitochondria are described and the resulting fraction is enzymatically characterized.(2) These mitochondria are able to accumulate Ca2+ in a respiration-dependent reaction without additions of Pi and/or adenine nucleotides.(3) As criteria the increased acidity of the incubation medium accompanying the energy-dependent Ca2+ accumulation, its inhibition by rotenon and Antimycin A, the acceleration of respiration and the redox change of the pyridine nucleotides were recorded and Ca2+ accumulation by the mitochondria was determined by complexemetric methods.(4) The maximum Ca2+ accumulation by rat brain mitochondria amounts to only 25 per cent of that by rat liver mitochondria under similar conditions (on the base per mg protein); after addition of 1 mm-ADP (without Pi) the comparable value was about 50 per cent.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-4159.1973.tb06034.x
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