ISSN:
0730-2312
Schlagwort(e):
bladder cancer
;
chemoprevention
;
MNU
;
model systems
;
mouse
;
OH-BBN
;
rat
;
retinoids
;
Life and Medical Sciences
;
Cell & Developmental Biology
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Biologie
,
Chemie und Pharmazie
,
Medizin
Notizen:
The chemopreventive efficacy of several compounds was evaluated in the N-butyl-N-(4-hydroxybuty) introsamine (OH)-BBN)-induced urinary bladder cancer model using C57BL/6xDBA/2F1 (BDF) male mice. Compounds were administered in a defined semipurified diet (AIN-76-A) either as single agents orin combination. As single agents and at the doses emplyed, 2-α-difluoromethylornithine (DFMO), piroxicam, oltpraz, and sodium moybdate effectively inhibited the incidence of trasitional cell carcinoma (TCC). 4-Hydroxyphenyl retinamide (4-HPR) was ineffective. Body weight gain and survival was not affected by thedoses of agents used. Combinations of two agents which increased efficacy were 4-HPR+DFMO, DFMO+piroxicam, 4-HPR+oltipraz, and DFMO+oltiprz. Three-agent combinations which showed enhanced efficacy against TCC induction were 4-HPR+Namolybdate+DFMO, 4-HPR+DFMO+piroxicam, and 4-HPR+DFMO+oltipraz. Although the three-agent combinations were, for the most part, no more effective than the two-agent combinations at the doses employed, all combination regmens signicantly reduced bladder incidence even when single agent administration did not. © 1992 Wiley-Liss, Inc.
Zusätzliches Material:
1 Tab.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/jcb.240501326
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