ISSN:
1365-2133
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The effect of short-term (mean 2-4 months), low-dose (5 mg/kg) cyciosporin A (CyA) on renal function and blood pressure was studied in eight patients with psoriasis. Studies were undertaken before, during and after treatment. Glomerular filtration rate (GHR) post-treatment was significantly higher than pretreatment or during treatment (pre. 119±7: during, 113±9: post. 133±11 ml/min per 1.73 m2: pre vs. during. NS: during vs. post. P〈0.01; pre vs. post, P〈0.05): effective renal plasma flow (ERPF) was unchanged (pre. 515±38; during, 485±49: post. 56±45 ml/min per 1.73 m2). There was no change in the urinary excretion of either albumin or the enzymes N-acetyl-glucosaminidase. lactate dehydrogenase. alanine aminopeptidase and alkaline phosphatase. There was a decrease in exchangeable sodium which persisted post-treatment (pre. 56±3; during. 49±3; post. 49±3 mmol/kgLBM: pre vs. during. P=0.07: during vs. post. NS: pre vs. post. P=0.06). Blood pressure assessed as either a single reading, or the mean of a 24 h ambulatory recording, increased during treatment (single reading: pre, 113/73; during. 126/83; post. 114/70 mmHg: mean 24 h: pre, 114/71: during. 123/76: post. 120/72 mmHg). Thus, short-term use of CyA at a dose of 5 mg/kg for the treatment of psoriasis is associated with a significant increase in blood pressure, but only a transient mild reduction in GFR, which did not reach significance.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-2133.1993.tb00234.x
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