ISSN:
1432-1432
Keywords:
Nucleoside bis-monophosphates
;
Nucleoside analogues
;
Cyclic pyrophosphates
;
Ring-opening polymerization
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary When 2′-deoxythymidine-3′,5′-cyclic diphosphate, or the cyclic pyrophosphates of the acyclic nucleoside analogues II and IV are heated to 65–85°C in the presence of imidazole, oligomers with lengths up to 20–30 are formed in excellent yield. This reaction provides a useful source of oligomers for use as templates in aqueous condensation reactions. In the absence of evidence to the contrary, we assume that the oligomers are atactic. The potential significance of this reaction in prebiotic chemistry is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02099935
Permalink