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Cardiac myxomas: Immunohistochemical study of benign and malignant variants (1991)

Curschellas, E. ; Toia, D. ; Borner, M. ; [et al.]

Springer

Virchows Archiv 418 (1991), S. 485-491

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ISSN: 1432-2307

Keywords: Cardiac myxoma ; Immunohistochemistry ; Histogenesis

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Immunohistochemical investigation of 11 cardiac myxomas (CMs) including one malignant metastasizing CM showed a co-expression of epithelial (lu-5 and CAM 5.2), mesenchymal (vimentin) and neuroendocrine antigens (neuron-specific enolase) in all tumour cells. Factor VIII was found in the endothelial cells of capillaries only. In the subendocardium of fetal heart tissue close to the foramen ovale myofibroblasts reacting with the panepithelial antibody lu-5 were detected. We conclude that CMs are neoplasms that may develop from embryonic cell remnants.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01606497

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